Scientific publications for BioPredictive non-invasive diagnostics
Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.
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“Liver fibrosis biomarkers”
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Assessment of liver fibrosis: noninvasive means.
…limits of the available biomarkers of liver fibrosis. Among a total of…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…invasive serum biomarkers, separately and in combinations, on liver fibrosis in treatment…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…the diagnosis of fibrosis in patients with chronic liver disease. This paper…
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Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
…Therefore suitable serological biomarkers of liver fibrosis are urgently needed. We used…
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Liver fibrosis markers in alcoholic liver disease.
…The assessment of the degree of liver fibrosis in alcoholic liver disease…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…the presence of fibrosis and steatosis, estimated using biomarkers FibroTest and SteatoTest…
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Noninvasive Assessment of Liver Fibrosis.
…There are two clinically relevant endpoints for the staging of liver fibrosis…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data.
### Background Liver biopsy is considered as the gold standard for assessing non…
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Non-invasive markers for hepatic fibrosis.
…biomarkers capable of non-invasive staging of fibrosis in the liver is…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…In conclusion, FibroTest and LSM were the most validated biomarkers of fibrosis…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
…invasive serum biomarkers with liver biopsies to predict liver fibrosis stage. HCV…
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FibroMAX: towards a new universal biomarker of liver disease?
…chronic liver diseases: FibroTest (BioPredictive) for the quantitative assessment of fibrosis; SteatoTest…
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Noninvasive diagnosis in alcohol-related liver disease. Review
…earlier features of advanced liver fibrosis, surrogate biomarkers and techniques have been…
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Biomarkers of liver fibrosis.
…limits of the available biomarkers of liver fibrosis. Among a total of…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy.
…fibrosis owing to the significant limitations of liver biopsy. Those biomarkers were…
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
### Background Liver biopsy is considered as the gold standard for assessing nonalcoholic…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…different prognostic serological biomarkers in predicting liver fibrosis severity in people with…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…of liver disease severity. ### Objective To compare the awareness of liver disease…
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
…The use of FibroTest (FT) and ActiTest (AT), biomarkers of fibrosis and…
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Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
…minimal liver disease. Discordance among the various biomarkers of fibrosis was considerate…
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The Distribution of Liver Steatosis, Fibrosis, Steatohepatitis and Inflammation Activity in Alcoholics According to FibroMax Test.
…liver diseases was assayed by means of non-invasive biomarkers: fibrosis by…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
…with or without chronic liver disease. Biomarkers and panels were assessed in…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
…liver fibrosis in hepatitis C-infected haemophiliacs using a combination of biomarkers…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers.
…Current biomarkers constitute predictive models (e.g. NAFLD fibrosis score, FIB-4…
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Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
…fibrosis and did not predict cirrhosis. ### Conclusions Abnormal biomarkers of hepatic fibrosis…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Routine assessment of liver fibrosis was requested by the surveyed physicians mostly…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
…comparison with liver biopsy, for the evaluation of hepatic fibrosis in patients…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…
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Noninvasive evaluation of NAFLD.
…fibrosis are at greatest risk of developing complications of end-stage liver…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study.
…Beyond its utility in assessing liver fibrosis, the FibroTest® could be a…
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
…of chronic hepatitis and hepatic fibrosis. Liver biopsy, because of its limitations…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.
…These indirect comparisons assumed that the gold-standard is binary, whereas fibrosis…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…biomarkers and TE could increase the diagnostic accuracy of liver fibrosis assessment…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
…fatty liver disease (NAFLD) should be evaluated for liver fibrosis. However, the…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
…ALD and available liver biopsy examination were included. Biomarkers were compared using…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Non-invasive biological tests have also been evaluated to assess liver fibrosis…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
…need for better biomarkers of drug-induced-liver-injury (DILI). ### Aims We…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease.
…the stage of fibrosis in non-alcoholic fatty liver disease (NAFLD) with…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
…and liver fibrosis (resmetirom) announce the widespread use of fibrosis tests in…
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts.
…However, it remains unclear whether NAFLD biomarkers could help estimate cardiovascular risk…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
### Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to…
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Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
…UK Biobank with apparently healthy liver participants (middle-aged, n=138,125…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…The third aim was to assess the long-term dynamics of fibrosis…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease.
…invasive fibrosis markers have been suggested as alternatives to liver biopsy in…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication
…interpretation of non-invasive biomarkers in liver fibrosis. A scoring system has…
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Meta-analyses of FibroTest diagnostic value in chronic liver disease.
### Background FibroTest (FT) is a biomarker of liver fibrosis initially validated in…
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Applicability and variability of liver stiffness measurements according to probe position.
### Aim To investigate the liver stiffness measurement (LSM) applicability and variability with…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
…To estimate liver fibrosis and to assess the concordance between FT and…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…compare noninvasive biomarkers, FibroTest and ActiTest in predicting fibrosis stage and inflammation…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.
…the fibrosis-4 index (FIB-4) and two activity biomarkers (alanine aminotransferase…
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies.
…repeated estimates of fibrosis per patient using biomarkers with at least two…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…At 10 years, among the 415 patients with baseline advanced fibrosis, 49…
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
…fatty liver disease leading to advanced fibrosis, cirrhosis, and liver cancer. We…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.
### Background Blood tests of liver injury are less well validated in non…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
### Background & Aims Liver fibrosis stage is traditionally assessed with biopsy, an imperfect…
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Poynard T, Ratziu V, Imbert-Bismut F, Munteanu M
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered the gold standard for assessing histologic lesions…
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Reproducibility of non-invasive fibrosis biomarkers, FibroMeter and FibroTest, could be improved by respecting the analytical standardizations.
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
…value of non-invasive biomarkers of liver fibrosis (FibroTest) and steatosis (SteatoTest…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…performance for fibrosis stage F2 (few septa) vs F1 (fibrosis without septa…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…tests (NITs) of liver fibrosis and to assess fibrosis progression over time…
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Poynard T, Imbert-Bismut F, Ratziu V, Myers RP, Di Martino V, Thabut D, Moussalli J, Benhamou Y
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
### Background & Aims Liver stiffness can be measured noninvasively to assess liver fibrosis…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…invasive fibrosis biomarkers may be influenced by aetiology of chronic liver disease…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
### Aim Of The Study Was to evaluate liver disease severity in children…
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Screening studies of transient elastography and FibroTest in the general population - Authors' reply.
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…fatty liver index score, non-alcoholic fatty liver disease fibrosis score, and…
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Effective use of FibroTest to generate decision trees in hepatitis C.
…fibrosis scores in clinical studies and improve our understanding of fibrosis progression.
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…one of the first composite liver fibrosis markers. This study aims, prospectively…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
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Evolution of biomarkers of liver fibrosis and liver insufficiency in hepatitis C virus-infected patients treated with pegylated interferon plus ribavirin and rituximab.
…on biomarkers of liver insufficiency in patients with severe liver fibrosis. Twenty…
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
…Similar impacts of ADV on liver fibrosis and activity were observed both…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis.
…fibrosis allows accurate diagnosis of cirrhosis and reduces the need for liver…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection.
…The detection and quantification of liver fibrosis is a key factor for…
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Screening studies of transient elastography and FibroTest in the general population.
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…in the prediction of primary liver cancer in patients without cirrhosis. ### Aim…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B.
…TE had lower performance than FibroTest for identifying advanced fibrosis in All…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
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Evolution of Non-alcoholic Fatty Liver Disease (NAFLD) Biomarkers in Response to Weight Loss 1 Year After Bariatric Surgery-a Post Hoc Analysis of the FibroTest Prospective Study.
…Histological data regarding intraoperative liver biopsy were collected at baseline, clinical, and…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
…Investigations included assessment of abdominal ultrasonography, liver biopsy, calculation of body mass…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
…competitor as a biomarker of liver fibrosis in comparison with the standard…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
…non-invasive liver fibrosis biomarkers for the prediction of significant liver fibrosis.
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
…I LVDD, fibrosis, mild steatosis, moderate-to-severe liver steatosis, mild MASLD…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…activity compared to conventional biomarkers. Assessing liver fibrosis is crucial for managing…
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Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.
…About 1/3 of carriers have moderate to severe liver fibrosis and…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
…liver fibrosis. The use of FT may decrease the need for liver…
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
…All patients in the cohort except 1 were managed without a liver…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
…steatosis, nonalcoholic steatohepatitis (NASH) and liver fibrosis. Patients underwent an objective assessment…
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Biomarkers for liver disease in urea cycle disorders.
…of several non-invasive biomarkers for liver fibrosis in UCDs. ### Methods We…
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Prevalence of liver fibrosis and cirrhosis in 699 Moroccan patients with chronic hepatitis C.
…population. ### Methods the prevalence of liver fibrosis and cirrhosis using a non…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
### Objectives To optimize the performance and feasibility of fibrosis blood tests and…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
### Background FibroTest(®) (FT), and liver stiffness measurement (LSM) are the most validated…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
…liver stiffness, and this result is an indirect measure of hepatic fibrosis…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
…By multivariate analysis, independent factors for liver steatosis were, as expected, triglyceride…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis.
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation.
…end stage (mild fibrosis to cirrhosis). Although, liver biopsy is still considered…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication
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Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.
Patients infected with hepatitis C virus (HCV) have differing levels of liver…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
…The Enhanced Liver Fibrosis (ELF) test consists of an algorithm of three…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…limited comparisons with other validated fibrosis biomarkers. The aim was to assess…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis.
…in the prediction of primary liver cancer in patients without cirrhosis. ### Aim…
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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
…followed for a risk of liver fibrosis risk in the USA (212…
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods.
…The staging of liver fibrosis still represents the most important prognostic problem…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…AshTest is an appropriate non-invasive alternative to transjugular liver biopsy.
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…2 specific blood tests for liver fibrosis in HCV/HIV co-infection…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
…Liver biopsy is the gold standard for assessing liver fibrosis and is…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
### Background & Aims Non-invasive assessment of liver fibrosis is a challenging area…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
…liver fibrosis assessment in HIV/HBV co-infection. Global performance of biomarkers…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
…of liver stiffness, non-invasive tests of liver fibrosis, and liver biopsy…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
…The prevalence of fibrosis≥F2 was 10% (CHB), 42% (CHC) and 21…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages].
…the biomarkers that are currently being used for studying liver fibrosis in…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
…Progressive liver injury is a concern in HIV-infected children exposed to…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…liver fibrosis and inflammation and can be considered an alternative to liver…
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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
…In univariate analysis, patients with liver fibrosis had more cardiovascular events and…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
…We hypothesized that specific tests for fibrosis developed for other chronic liver…
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GlycoFibroTest is a highly performant liver fibrosis biomarker derived from DNA sequencer-based serum protein glycomics.
Liver fibrosis is currently assessed by liver biopsy, a costly and rather…
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated…
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A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication
### Background FibroTest, a noninvasive method of measuring biomarkers of liver fibrosis, is…
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The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women.
…Given that early identification of non-alcoholic fatty liver disease (NAFLD) is…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
…painful liver biopsy. Consequently, the highly specific set of biomarkers presented could…
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Hepatitis B: are non-invasive markers of liver fibrosis reliable?
…a 'biological' approach, based on the quantification of biomarkers of fibrosis in…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…liver biopsies along with FT and transient elastography were prospectively enrolled. Fibrosis…
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Noninvasive assessment of portal hypertension in patients with cirrhosis.
…investigate the development of hepatic fibrosis through the measurement of increased intrahepatic…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…transient elastography (TE) and biomarkers for liver fibrosis assessment and follow-up…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
…FibroTest®, FibroMeter®, and HepaScore® for liver fibrosis in hepatitis B compared to…
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Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
…However, in the male group, the intensity of liver fibrosis was higher…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis.
### Background Liver fibrosis is a sign of advanced liver disease and is…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
…patented blood test for diagnosing fibrosis or cirrhosis in patients with chronic…
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Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
…serum-based assessment of liver fibrosis is still an important diagnostic challenge…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
…Liver fibrosis was measured with shear wave elastography and FibroTest. The risk…
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
…Both markers have the required sensitivity and specificity to detect liver fibrosis…
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Fibromax-based nonalcoholic fatty liver disease in chronic obstructive pulmonary disease patients with obstructive sleep apnea: Methodological considerations.
…to determine the prevalence of liver fibrosis, steatosis and nonalcoholic steatohepatitis (NASH…
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…Liver fibrosis was evaluated according to the METAVIR scoring system on a…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C.
### Objective Blood tests are usually designed to identify significant fibrosis. We evaluated…
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FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
### Background Noninvasive markers of liver fibrosis have not been extensively studied in…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…CHC in which fibrosis was evaluated by liver biopsy (Metavir) and tests…
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
…liver and one taking into account the prevalence of each fibrosis stage…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…and inexpensive biomarker to delineate liver fibrosis in chronic hepatitis C. ### Aim…
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Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…We aimed to compare blood fibrosis tests and liver stiffness measurement (LSM…
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis.
### Objectives Extent of liver fibrosis is one of the most important factors…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
### Background Assessment of fibrosis progression in chronic liver disease relies upon non…
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[Prognosis assessment of alcoholic liver disease: how and why?].
Alcoholic liver disease (ALD) causes more than 5000 deaths per year in…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review.
…the infection, have developed advanced liver disease. Until recently, in order to…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
…liver fibrosis received transient elastography and examinations for serum markers of fibrosis…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
…marker of liver fibrosis in patients with cystic fibrosis. Increased APRI values…
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Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
…Biomarkers could be useful for screening of advanced fibrosis and NASH in…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure.
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
### Background Non-invasive liver fibrosis scores have been proposed as alternatives to…
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
…and non-invasive quantitative estimate of liver fibrosis reliably predicts advanced fibrosis.
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not…
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
…The best marker of liver fibrosis in alcoholic patients seems to be…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…scores (FibroTest®, Fibrometer®) to diagnose liver fibrosis in Senegalese CHB patients with…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
…method to assess liver fibrosis by measuring liver stiffness in adult patients…
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Diagnosis of fibrosis and cirrhosis. Liver biopsy is not always necessary.
…liver is considered the "gold-standard" for diagnosis of hepatic fibrosis and…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
…Baseline liver biopsies were evaluated for METAVIR fibrosis by a single pathologist…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…diagnosis of advanced fibrosis and cirrhosis in chronic liver disease. However, there…
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Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis.
…Newly developed elastography based techniques seem promising to estimate liver fibrosis. Other…
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The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
-
Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.
…We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the…
-
Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.
…associated with the risk of liver fibrosis, inflammation (NASH), and COVID-19…
-
Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…Histopathological staging of liver fibrosis according to the METAVIR scoring system served…
-
A novel panel of blood markers to assess the degree of liver fibrosis.
…In conclusion, the pathological staging and area of liver fibrosis can be…
-
Altered serum N-glycomics in chronic hepatitis B patients.
…Liver fibrosis was staged using Ishak score. N-glycan profiles of serum…
-
Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
…F0-F3, mild fibrosis; and A2/A3-A3, advanced vs. A0-A2…
-
Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
### Aim The objective of this study was to evaluate liver fibrosis using…
-
An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…significant liver fibrosis (Metavir score >or= 2) compared with liver biopsy. ### Methods…
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[The diagnostic value of non-invasive biochemical biomarkers in alcohol abuse].
### Unlabelled The diagnosis of alcoholic liver disease, steatosis, fibrosis and alcoholic steatohepatitis…
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Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
…with cystic fibrosis (CF). However, detection of CF-associated liver disease (CFLD…
-
Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
…Results of noninvasive liver fibrosis markers were as follows: fibrotest,-1.65…
-
External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV.
### Background & Aims The Liver Cancer Risk test algorithm (LCR1-LCR2) is a…
-
Assessment of methotrexate hepatotoxicity in psoriasis patients: a prospective evaluation of four serum fibrosis markers.
…However, its use is hampered by the risk of liver fibrosis. ### Aim…
-
Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…Evaluation of liver fat was performed using four noninvasive methods: the SteatoTest…
-
Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.
…is the prediction of metabolic liver disease (MLD) by noninvasive tests (NITs…
-
Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…liver disease-fibrosis score. A LB was indicated if suspected significant fibrosis…
-
Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
-
Non-invasive diagnosis of hepatitis B virus-related cirrhosis.
…These include measurements of serum biomarkers of fibrosis; and assessment of liver…
-
The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
…fibrosis and/or activity, and decreases the need for a liver biopsy…
-
Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis.
…The combination of both approaches as first-line assessment of liver fibrosis…
-
Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…Histologic staging of liver fibrosis served as the reference standard. ### Results Liver…
-
Letter: APRI and FIB-4 do not correlate with Fibrosure in the evaluation of liver fibrosis in hepatitis C patients.
-
Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection.
### Background Accurately staging hepatitis C virus (HCV)-related fibrosis is crucial for…
-
Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
-
Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
…fatty liver, but coffee intake may exert beneficial effects on fibrosis progression.
-
Management of the patient with SVR. Review
…SVR benefits are well-recognized with reductions in rates of liver complications…
-
Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…detailed fibrosis classifications available for non-invasive tests and liver biopsy. The…
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A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.
…test and liver stiffness measurement (LSM) to stage liver fibrosis in chronic…
-
Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
…Few studies investigated noninvasive markers of liver fibrosis in hepatitis C virus…
-
Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.
…or excluding liver fibrosis, thus reducing the need for liver biopsy. However…
-
Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
…the degree of liver fibrosis as determined by liver biopsy. In addition…
-
Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…explained the false positivity of liver fibrosis staging using ARFI LSM. ### Conclusions…
-
Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.
-
FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…
-
Alpha-2-macroglobulin and hepatic fibrosis. Diagnostic interest.
…fibrosis among drinkers, particularly in patients without clinical symptoms of liver failure…
-
Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
…Non-invasive panels for the diagnosis of steatosis, NASH and/or fibrosis…
-
Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study.
…fibrosis and activity for use as a non-invasive alternative to liver…
-
Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…Validated non-invasive tests for liver fibrosis consistently detected otherwise unrecognised liver…
-
Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…Nevertheless, a concerning amount of liver fibrosis progression did occur, which could…
-
Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…CHC in which fibrosis was evaluated by liver biopsy (Metavir) and tests…
-
Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
…Severe fibrosis was predicted when FibroTest was >0.59 or liver stiffness…
-
Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
-
FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
-
Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
…Fibrotest and Forns scores were compared with liver fibrosis pathology scored according…
-
Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
-
Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…elastography (Fibroscan™) to assess liver fibrosis, vs. liver biopsy, in untreated patients…
-
Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
-
Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
…as alternatives to liver biopsy for identifying fibrosis or cirrhosis. ### Purpose To…
-
Role of genotype G hepatitis B virus mixed infection on the progression of hepatic fibrosis in HIV positive patients over 5 years of follow-up.
…The impact of HBV-G on liver fibrosis progression, as assessed by…
-
Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
…of fibrosis and the degree of necroinflammatory activity in the liver. In…
-
Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
-
External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B.
### Background And Aims The liver cancer risk test (LCR1-LCR2) is a…
-
Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
…alcohol-related liver disease (ArLD) is increasing, and liver fibrosis stage is…
-
Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…fibrosis tests are more accurate than liver biopsy for determining liver prognosis…
-
[SWE elastography in assessment of liver fibrosis].
Liver fibrosis is a relatively common consequence of chronic liver diseases, especially…
-
Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…Other than fibrosis, other factors independently associated with liver stiffness were ALT…
-
Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes.
…the prediction of non-alcoholic liver disease by non-invasive blood tests…
-
Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
Liver fibrosis (LF) must be assessed before talking treatment decisions in hepatitis…
-
Relationship between the Fibrotest and portal hypertension in patients with liver disease.
…12%, moderate fibrosis 17%, cirrhosis 71%). There was a significant correlation between…
-
An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
-
Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
…a noninvasive method to assess liver fibrosis in HCV on a scale…
-
Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…one approach assumed a uniform prevalence distribution of each fibrosis stage; the…
-
Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…of non-invasive markers for liver fibrosis in hepatitis C may improve…
-
FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
…and inexpensive method for assessing liver fibrosis and proved to be concordant…
-
Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
…used in the evaluation of liver fibrosis in HCV positive immune-competent…
-
The non-invasive assessment of hepatic fibrosis.
…Liver fibrosis, as the last stage of numerous chronic liver diseases, is…
-
Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…performance in the prediction of liver fibrosis in patients with chronic hepatitis…
-
Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial.
A liver fibrosis index was recently prospectively validated in a cross-sectional…
-
Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
-
Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
-
Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
### Background The main causes of liver fibrosis in transfusion-dependent thalassemia major…
-
Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
-
Late presentation of chronic viral hepatitis for medical care: a consensus definition.
### Introduction We present two consensus definitions of advanced and late stage liver…
-
Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
…Liver fibrosis and necroinflammatory activity was staged and graded according to the…
-
Impact of steatosis and inflammation definitions on the performance of NASH tests.
…We reviewed the landmark studies in metabolic liver disease, sources of the…
-
Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
The diagnostic utilities of ultrasonography (US), fatty liver index (FLI) and an…
-
Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
…However, the sensitivity, specificity and diagnostic accuracy in evaluating liver fibrosis of…
-
Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.
…The logistic regression equations for diagnosing liver fibrosis and early cirrhosis were…
-
Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
…liver biopsy and serum were tested for markers of liver fibrosis. ### Methods…
-
Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…Histological features were assessed invasively by liver biopsy and noninvasively using FibroTest…
-
Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
-
PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
…In multivariate analysis, the predictive variables for advanced liver fibrosis were age…
-
Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy.
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
-
Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…as non-invasive alternatives to liver biopsy (LB) in 138 HCV-infected…
-
Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
### Background FibroTest has been validated for the diagnosis of liver fibrosis in…
-
Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
…chronic liver disease and either histological assessment of liver fibrosis (n = 112…
-
Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…agonists and not antagonists towards the common goal of estimating liver fibrosis.
-
Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…to evaluate dynamic changes of liver fibrosis and steatosis within 12 mo…
-
Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
### Objectives Liver fibrosis in chronic hepatitis C is related to sex, age…
-
Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…
-
Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
…clinically significant fibrosis (including early stages). ### Methods We assessed liver-biopsy patients…
-
Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.
…infected patients with an advanced liver fibrosis stage. ### Conclusions Median plasma C…
-
Noninvasive prediction of fibrosis in patients with chronic hepatitis C.
-
Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
### Background And Aim Significant hepatic fibrosis is prognostic of liver morbidity and…
-
Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
### Background & Aims The reliability of transient elastography (TE) to assess liver fibrosis…
-
SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
### Unlabelled The staging of liver fibrosis is pivotal for defining the prognosis…
-
Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
…Such discordance is of little clinical consequence for liver fibrosis evaluation in…
-
Guidelines for the diagnosis of uncomplicated cirrhosis.
-
Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
### Background & Aims Patients with chronic hepatitis C virus infection and advanced fibrosis…
-
A simple biological index for detection of alcoholic liver disease in drinkers.
…liver disease (serum gamma-glutamyl transpeptidase), and a test for liver fibrosis…
-
Biopsy as well as FibroTest/Fibrosure is suboptimal for discriminating intermediate fibrosis stages in patients with chronic hepatitis B.
-
Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…The combined use of FibroScan and FibroTest to evaluate liver fibrosis could…
-
Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
…The noninvasive measurement of liver fibrosis using transient elastography and fibrosis marker…
-
Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…invasive tests for liver fibrosis [the Enhanced Liver Fibrosis (ELF™) test (Siemens…
-
Reproducibility of blood tests of liver fibrosis in clinical practice.
…reproducibility of blood test for liver fibrosis: FibroMeter, Fibrotest, APRI and their…
-
Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
…gold standard for assessment of liver fibrosis. Non-invasive markers have been…
-
Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
As an alternative to liver biopsy, an index of five biochemical markers…
-
Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…fibrosis progression occurs. We aimed to verify whether monitoring by liver biopsy…
-
Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
…liver biopsy. A new fibrosis classification that synchronously combines two fibrosis tests…
-
A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
### Objectives Precise evaluation of the level of liver fibrosis is recommended in…
-
Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
…Non-invasive methods for the diagnosis of liver fibrosis, such as transient…
-
Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
Transient elastography (TE) is a noninvasive technique to evaluate liver fibrosis. We…
-
Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…liver stiffness, but not with fibrosis and activity grade on liver biopsy…
-
Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…more complex scores in determining fibrosis stage in 157 patients transplanted for…
-
La Haute Autorite de Sante (HAS) in France— Diagnosis of uncomplicated cirrhosis (Accessed December 2011)
-
Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
### Background Non-invasive liver fibrosis scores such as Hepascore (HS) have been…
-
The use of enzyme results for liver fibrosis evaluation neccessitates standardization.
-
Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
…liver biopsy (LB) remains the gold standard to assess liver fibrosis in…
-
Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
### Background/Aims Non-invasive markers of liver fibrosis have recently been developed…
-
Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.
### Background The FibroTest and ActiTest are noninvasive biochemical markers of liver injury…
-
Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
…Blood tests could be useful to assess liver fibrosis changes in clinical…
-
EASL clinical practical guidelines: management of alcoholic liver disease.
-
Implementing non-invasive markers for liver fibrosis in clinical practice.
-
The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease.
…patients with chronic alcoholic liver disease. ### Methods Biomarkers were assessed in patients…
-
FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy.
### Background The accurate diagnosis of hepatitis C virus (HCV)-related fibrosis is…
-
Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
…being developed as alternatives to liver biopsy in patients with chronic hepatitis…
-
Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
-
Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
…on reducing steatosis, NASH or liver fibrosis even after adjustment for gender…
-
Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
### Background Aims Liver biopsy is the gold standard for assessing hepatitis B…
-
Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
Liver fibrosis and activity indexes were validated in patients infected by hepatitis…
-
Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…TPP) of blood tests of liver fibrosis. ### Methods Three hundred and fifty…
-
Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests. Key publication
### Background Systematic screening for liver fibrosis in heavy-drinking patients is a…
-
Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study.
…As portal hypertension is related to liver fibrosis, this study aimed to…
-
Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
-
Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection
-
The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
-
Non-invasive assessment of liver fibrosis: are we ready?
-
Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
### Unlabelled Males have strikingly increased risk of advanced liver disease. However, the…
-
Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…method for the evaluation of liver fibrosis and cirrhosis. ### Aim To determine…
-
Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
…A higher percentage of controls (66.0%) than patients with advanced fibrosis…
-
Discordance between biochemical markers of liver activity and fibrosis (Actitest-Fibrotest) and liver biopsy in patients with chronic hepatitis C.
…and fibrosis as compared with the histological analysis of liver biopsy. Clinicians…
-
The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
…ELF, ≥10.43; Nonalcoholic Fatty Liver Disease Fibrosis Score, ≥1.80; Fibrotest…
-
FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
…genotype 2/3 (odds ratio=2.9), fibrosis estimated with FT (4…
-
Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry.
…Features suggestive of hepatic fibrosis were observed on ultrasound in 87/143…
-
Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis.
…25(OH)D3] and severe liver fibrosis and low sustained virologic response…
-
Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…liver biopsy by classifying patients into three categories: no cirrhosis; significant fibrosis…
-
Changes of non-invasive markers and FibroScan values during HCV treatment.
…Liver fibrosis was staged with FibroScan and Fibrotest at inclusion, then every…
-
HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
…The hypothesis was that fibrosis stage estimated with FibroTest instead of biopsy…
-
Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…liver fibrosis. ### Methods Five blood tests were compared with Metavir fibrosis (F…
-
Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease.
### Unlabelled Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance…
-
Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
-
EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
-
Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…At baseline, bridging fibrosis (METAVIR stages F2-F3-F4) was highly associated…
-
Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…were performed the day of liver biopsy (LB), taken as reference, in…
-
[The value of noninvasive serological markers in hepatitis B].
Bloodless methods (serological and imaging) for evaluating hepatic fibrosis constitute a good…
-
Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
…All children showed significant liver fibrosis (F3 [n = 3]; F2 [n = 1…
-
[Alpha 2 macroglobulin immunoturbidimetric assays (DakoCytomation reagents) on Roche Diagnostic analysers (Modular P, Cobas Integra). Application to FibroTest-Actic-Test].
…Progresses in the comprehension of fibrosis dynamics and better treatment efficacy follow…
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