Personalized management of cirrhosis by non-invasive tests of liver fibrosis.

Wong GL, Espinosa WZ, Wong VW

Abstract

Owing to the high prevalence of various chronic liver diseases, cirrhosis is one of the leading causes of morbidity and mortality worldwide. In recent years, the development of non-invasive tests of fibrosis allows accurate diagnosis of cirrhosis and reduces the need for liver biopsy. In this review, we discuss the application of these non-invasive tests beyond the diagnosis of cirrhosis. In particular, their role in the selection of patients for hepatocellular carcinoma surveillance and varices screening is highlighted.

Keywords — author-chosen FibroScan, FibroTest, Hepatocellular carcinoma, Transient elastography, Varices

MeSH — NLM indexing Biomarkers / blood Carcinoma, Hepatocellular / diagnosis Elasticity Imaging Techniques Endoscopy, Digestive System Humans Hypertension, Portal / complications Liver Cirrhosis / complications Liver Cirrhosis / diagnosis Liver Neoplasms / diagnosis Risk Factors