Scientific publications for BioPredictive non-invasive diagnostics
Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.
407/433
Matches for
“Liver cirrhosis”
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation.
…stage (mild fibrosis to cirrhosis). Although, liver biopsy is still considered as…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Prevalence of liver fibrosis and cirrhosis in 699 Moroccan patients with chronic hepatitis C.
…The older age was independently associated with liver cirrhosis.
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Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…54 ± 11 years) with chronic liver disease and established cirrhosis were included…
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Non-invasive diagnosis and follow-up of portal hypertension.
…chronic liver disease (cACLD) describes the spectrum of advanced fibrosis/cirrhosis in…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.
…cirrhosis plays an important role in clinical and therapeutic decision-making. Liver…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease.
…to alcoholic steatohepatitis and cirrhosis. Fatty liver develops in more than 90…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…prediction of primary liver cancer in patients without cirrhosis. ### Aim To construct…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
…of the severity of liver fibrosis and cirrhosis in PSC patients and…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection.
…the end-stage liver disease such as decompensated cirrhosis and hepatocellular carcinoma…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…The cirrhosis detection rate increased from 26 to 65% by performing liver…
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Liver fibrosis markers in alcoholic liver disease.
Alcohol is one of the main factors of liver damage. The evaluation…
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Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…NPV for cirrhosis, with 50%-80% reduced need for liver biopsy. ### Conclusion…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
…liver biopsies avoided does not differ between algorithms for diagnosing cirrhosis, it…
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Management of the patient with SVR. Review
…SVR benefits are well-recognized with reductions in rates of liver complications…
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…liver biopsy (LB), taken as reference, in 298 consecutive CHC patients (cirrhosis…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…of advanced fibrosis and cirrhosis in chronic liver disease. However, there is…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
…The current 'gold standard' for liver cirrhosis detection is an invasive, costly…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
…the detection of cirrhosis, obviating 81.5% of liver biopsies. A third…
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Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
…hepatic fibrosis or cirrhosis. ### Methods Subjects who had liver biopsy and FibroSure…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
### Background And Aims Blood tests and liver stiffness evaluation (LSE) by ultrasonographic…
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters?
…liver cirrhosis for at least three reasons: 1) the presence of cirrhosis…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
…alternatives to liver biopsy for identifying fibrosis or cirrhosis. ### Purpose To evaluate…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
### Background & Aims The reliability of transient elastography (TE) to assess liver fibrosis…
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Severity of Fontan-Associated Liver Disease Correlates with Fontan Hemodynamics.
…Severe liver cirrhosis was detectable in 20 patients (17.1%). Median liver…
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Noninvasive assessment of portal hypertension in patients with cirrhosis.
Severe portal hypertension is responsible for complications and death. Although measurement of…
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Guidelines for the diagnosis of uncomplicated cirrhosis.
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…significant liver fibrosis (METAVIR ≥F2), advanced liver fibrosis (≥F3) and cirrhosis (F4…
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C.
…Observed 100% negative predictive values for severe fibrosis and cirrhosis were, respectively…
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Relationship between the Fibrotest and portal hypertension in patients with liver disease.
…Conclusion In patients with liver disease or cirrhosis, Fibrotest is correlated with…
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…for advanced liver fibrosis (0·9-2·0%) or cirrhosis (0·1…
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Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.
…The logistic regression equations for diagnosing liver fibrosis and early cirrhosis were…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…This resulted in twice as many cases of cirrhosis being detected, 2…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
### Background And Aims Liver stiffness measurement (LSM) and FibroTest (FT) are frequently…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis.
Owing to the high prevalence of various chronic liver diseases, cirrhosis is…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
…cirrhosis (F4). ### Methods A total of 1013 HCV monoinfected cases undergoing liver…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis.
…prediction of primary liver cancer in patients without cirrhosis. ### Aim To construct…
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Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: Systematic review and meta-analysis. Review
…Since HBV-related cirrhosis is an indication for immediate antiviral therapy and…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis.
The limitations of liver biopsy (invasive procedure, sampling errors, inter-observer variability…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
…Although the diagnosis of cirrhosis may rely on non-invasive tests, liver…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…However, liver biopsy is not replaceable, especially to diagnose ≥F2 and in…
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Noninvasive Assessment of Liver Fibrosis.
…of liver fibrosis with the risk of developing cirrhosis. Liver biopsy, traditionally…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
…We aimed to validate its diagnostic performances in comparison with liver stiffness…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…Histologic staging of liver fibrosis served as the reference standard. ### Results Liver…
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
…The use of FT may decrease the need for liver biopsy examination.
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
…liver biopsy for the diagnosis of cirrhosis in children with chronic liver…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
### Background And Aim Significant hepatic fibrosis is prognostic of liver morbidity and…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy.
…For cirrhosis, the areas under the SROC curve for APRI, FIB-4…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests. Key publication
### Background Systematic screening for liver fibrosis in heavy-drinking patients is a…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
…Despite virological response, the overall incidence of cirrhosis increased, with a remaining…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…in cirrhosis cases, and a remaining 5% risk of primary liver cancer.
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
…primary biliary cirrhosis (PBC) for the assessment of liver fibrosis and steatosis…
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Altered serum N-glycomics in chronic hepatitis B patients.
…markers for the diagnosis of cirrhosis in patients with chronic hepatitis C…
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The Distribution of Liver Steatosis, Fibrosis, Steatohepatitis and Inflammation Activity in Alcoholics According to FibroMax Test.
### Background The diagnosis of alcoholic liver diseases is based on the history…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
…The study included 1785 patients with chronic hepatitis C, liver biopsy, blood…
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Hepatitis B: are non-invasive markers of liver fibrosis reliable?
…However, as none are liver specific their results can be influenced by…
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Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
### Background Liver biopsy is the reference standard for assessing liver fibrosis and…
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
…The best marker of liver fibrosis in alcoholic patients seems to be…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV.
### Background & Aims The Liver Cancer Risk test algorithm (LCR1-LCR2) is a…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…cirrhosis. However, aspartate aminotransferase levels must be considered when interpreting liver stiffness…
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis.
…The area under the hierarchical summary receiver operating curve for liver cirrhosis…
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Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
Serum bile acids (SBAs) are commonly elevated in cholestatic liver diseases, but…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
Transient elastography (TE) is a noninvasive technique to evaluate liver fibrosis. We…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
…Need for liver biopsy is reduced by 50-70% but cannot be…
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The non-invasive assessment of hepatic fibrosis.
…Liver fibrosis, as the last stage of numerous chronic liver diseases, is…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
…A total of 218 consecutive patients with ALD and available liver biopsy…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
### Background & Aims Liver stiffness can be measured noninvasively to assess liver fibrosis…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
### Background & Aims Liver fibrosis stage is traditionally assessed with biopsy, an imperfect…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis.
…Twenty-three percent of patients with CHB progress naturally to liver cirrhosis…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.
…In this case, liver biopsy is still required to properly assess liver…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…cirrhosis (CirrhoMeter) were included. Significant liver-related events (SLRE) and liver-related…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
### Background Liver stiffness and non-invasive tests predict overall survival in chronic…
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Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy.
…liver function and higher sustained virologic response rates than patients with cirrhosis.
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Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
…Blood tests were performed the day of the liver biopsy. Histological lesions…
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…Liver biopsy may be used in patients with suspected ALD to confirm…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
…included 1056 HCV patients with liver biopsy and blood markers. Validation populations…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
### Background FibroTest(®) (FT), and liver stiffness measurement (LSM) are the most validated…
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
…assessment of liver fibrosis (n = 112) or proven liver cirrhosis (n = 22…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
…Liver biopsy samples, NIT results, and PROs (Short Form-36, Chronic Liver…
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Non-invasive markers for hepatic fibrosis.
…The rate of adoption of non-invasive diagnostic tests for liver fibrosis…
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…liver biopsy, in untreated patients with chronic hepatitis C (CHC). ### Methods This…
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
…for nonalcoholic fatty liver disease leading to cirrhosis. Existing guidelines do not…
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Noninvasive evaluation of NAFLD.
…Ultrasonography-based transient elastography can exclude advanced fibrosis and cirrhosis, but its…
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Noninvasive diagnosis in alcohol-related liver disease. Review
### Background Alcohol-related liver disease (ALD) represents a major cause of death…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
…Although liver biopsy is still the gold standard to diagnose liver fibrosis…
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A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
### Objectives Precise evaluation of the level of liver fibrosis is recommended in…
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Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study.
…a non-invasive alternative to liver biopsy in patients with chronic hepatitis…
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Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
…Liver cirrhosis (TE values > 12.5kPa) was encountered in 23.5% and…
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
…fatty liver disease leading to advanced fibrosis, cirrhosis, and liver cancer. We…
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Liver fibrosis in adults with Fontan palliation: Do common screening studies predict disease severity?
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Non-invasive assessment of liver fibrosis: are we ready?
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
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Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis.
### Background & Aims In patients with compensated alcohol-related cirrhosis, reliable prognostic biomarkers…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.
### Background & Aims Alcohol is the leading cause of cirrhosis and liver-related…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
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Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis.
…5800 patients with virus C cirrhosis received fully reimbursed DAA therapy with…
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Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study.
…As portal hypertension is related to liver fibrosis, this study aimed to…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…AUROC for cirrhosis (F4) was 0.97 for TE followed by FIB…
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Diagnosis of fibrosis and cirrhosis. Liver biopsy is not always necessary.
Needle biopsy of the liver is considered the "gold-standard" for diagnosis…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy.
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review.
…the infection, have developed advanced liver disease. Until recently, in order to…
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Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
…Prevalence of significant liver-fibrosis assessed by TE, ARFI-right-liver-lobe…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
…However, the sensitivity, specificity and diagnostic accuracy in evaluating liver fibrosis of…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
…To estimate liver fibrosis and to assess the concordance between FT and…
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
…Liver biopsy, because of its limitations and risks, might be considered an…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B.
…APRI [0.05 (0.03-0.07)] and for identifying cirrhosis TE…
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
### Aim The objective of this study was to evaluate liver fibrosis using…
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Clinical applicability of non-invasive markers for liver fibrosis in chronic hepatitis C (Letter)
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Role of Non-hepatic Medical Comorbidity and Functional Limitations in Predicting Mortality in Patients with HCV.
…We defined cirrhosis with the FibroSure test (F3/4-F4). We used…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
…and C cause liver fibrosis, leading to cirrhosis. Fibrosis assessment is essential…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
…The AUROC for the diagnosis of liver cirrhosis was 0.92 (95…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…for advanced fibrosis 0.90 (0.72-0.99); for cirrhosis 0…
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The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C.
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Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
…risk of developing liver fibrosis and liver cirrhosis. The risk increases with…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
### Introduction A prognostic model to predict liver severity in people with metabolic…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.
…enrolled 103 patients for whom liver biopsy, hepatic elastography results, and laboratory…
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Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.
…liver disease progression and hepatocellular carcinoma, particularly in those with compensated cirrhosis.
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…In comparison with liver biopsy alone, there was a cost savings of…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
Changes in the liver and bile ducts observed in patients diagnosed with…
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B.
### Background And Aims The liver cancer risk test (LCR1-LCR2) is a…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
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Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
…hepatomegaly in 10, and cirrhosis in two. Liver stiffness as quantified by…
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Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups.
### Background Our aim was to assess the natural history of liver fibrosis…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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Combination of fibrosis tests: sequential or synchronous?
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Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
…Among patients with cirrhosis 96% (212/220) achieved sustained virological response 12…
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
…risk for intestinal failure-associated liver disease (IFALD). The aim of the…
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Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection.
…The prevalence of significant fibrosis and cirrhosis were 51% and 16%, respectively…
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…For the diagnosis of cirrhosis using LCM, SWE specificities were all equal…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…elastography (TE) and biomarkers for liver fibrosis assessment and follow-up of…
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…including hepatic necroinflammatory activity, on liver stiffness measurement (LSM). This prospective study…
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered as the gold standard for assessing non…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease.
…Ten year survival (95% CI) without liver-related death in patients with…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
### Background Liver biopsy is thought mandatory for management of patients with hepatitis…
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A novel panel of blood markers to assess the degree of liver fibrosis.
…In conclusion, the pathological staging and area of liver fibrosis can be…
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Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B.
### Background & Aims Data on liver fibrosis evolution and its involvement in liver…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
…The Kappa index was used to study overall agreement with liver biopsy…
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Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
…Among the 2,169 patients who underwent liver biopsy, bridging fibrosis (F2…
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The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
### Background Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Routine assessment of liver fibrosis was requested by the surveyed physicians mostly…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis.
### Background Liver fibrosis is a sign of advanced liver disease and is…
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HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.
…Liver-related and non-liver-related outcomes were documented. Overall 213 episodes…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…patients with chronic liver disease or normal liver tissue that surrounded tumors…
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Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
### Aim To assess the diagnostic value of Fibrotest in comparison with liver…
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
…Here, we aimed to identify predictors of discordance between FT and liver…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
…Histopathological staging of liver fibrosis according to the METAVIR scoring system served…
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Guidelines for the screening, care and treatment of persons with hepatitis C infection Key publication
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…We also examined the inter-observer variations after independent review of liver…
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
### Objective Liver biopsy, the gold standard for assessing hepatitis C virus (HCV…
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
### Background/Aims To compare non-invasive biological liver fibrosis scores, as alternatives…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
…Non-invasive methods for the diagnosis of liver fibrosis, such as transient…
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Late presentation of chronic viral hepatitis for medical care: a consensus definition.
### Introduction We present two consensus definitions of advanced and late stage liver…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
…When the FibroScan and FibroTest results agreed, liver biopsy examination confirmed them…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
### Introduction Hepatitis C virus (HCV) is the major cause of chronic liver…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
…e.g. >/=90%) where a liver biopsy can be avoided. ### Aims To…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…The aim of this study was to evaluate the evolution of liver…
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An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
Chronic hepatitis C remains a significant medical and economic burden in Canada…
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.
### Background The FibroTest and ActiTest are noninvasive biochemical markers of liver injury…
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FibroStic: a large confirmatory study for non-invasive biomarkers accuracy, if correctly interpreted.
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
…the entire liver and one taking into account the prevalence of each…
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EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
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Retracted: Executive functions in chronic hepatitis C virus infected elderly patients.
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Changes of non-invasive markers and FibroScan values during HCV treatment.
…The aim of this prospective study was to evaluate changes in liver…
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Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
### Background Non-invasive liver fibrosis scores such as Hepascore (HS) have been…
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Fibroscan and FibroTest/FibroMax to assess liver fibrosis/cirrhosis in patients with chronic HBV and HCV infection in Georgia.
…The aim of the study was to evaluate liver fibrosis/cirrhosis using…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
…The aim of the study was to improve the estimation of liver…
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Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
### Background Liver biopsy is an imperfect gold standard for assessing the disease…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…infection or non-HCV-related liver diseases. ### Methods And Results The optimal…
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La Haute Autorite de Sante (HAS) in France— Diagnosis of uncomplicated cirrhosis (Accessed December 2011)
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
…of the liver biopsy (up to 0.94 for liver biopsies >or…
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Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.
…This study aimed to assess the accuracy of ARFI in discriminating liver…
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Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.
…There were significantly more cases of discordances between APRI and liver biopsy…
-
Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…Metavir staging of liver specimens by two independent pathologists and the following…
-
Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…one of the first composite liver fibrosis markers. This study aims, prospectively…
-
Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients.
### Background Determining the stage of fibrosis by liver biopsy is important in…
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
As an alternative to liver biopsy, an index of five biochemical markers…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
…The main endpoint was the absence of liver-related complications, transplantation or…
-
The new paradigm of hepatitis C therapy: integration of oral therapies into best practices.
…Assessments of histologic damage typically are performed using liver biopsy, yet noninvasive…
-
FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
-
Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
-
Input of serum haptoglobin fucosylation profile in the diagnosis of hepatocellular carcinoma in patients with non-cirrhotic liver disease.
…patients with chronic liver disease including those without cirrhosis. Its combination with…
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Evolution of biomarkers of liver fibrosis and liver insufficiency in hepatitis C virus-infected patients treated with pegylated interferon plus ribavirin and rituximab.
…Twenty-eight untreated HCV-related vasculitis patients with severe liver fibrosis (Metavir…
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Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
…Fibrotest and Forns scores were compared with liver fibrosis pathology scored according…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
### Background HIV-monoinfected individuals are at high risk of nonalcoholic fatty liver…
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Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study.
…fibrotic liver disease that can lead to cirrhosis. While liver biopsy is…
-
Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial.
A liver fibrosis index was recently prospectively validated in a cross-sectional…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
### Background Non-invasive liver fibrosis scores have been proposed as alternatives to…
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Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
…Blood tests could be useful to assess liver fibrosis changes in clinical…
-
Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
### Background And Aims Chronic hepatitis C (HCV) is a liver disease affecting…
-
Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
-
Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
…To estimate liver fibrosis in haemophilia patients infected with hepatitis C (HCV…
-
Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.
Hepatitis C virus (HCV) infection is a major cause of chronic liver…
-
Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…as non-invasive alternatives to liver biopsy (LB) in 138 HCV-infected…
-
Diagnostic algorithms for liver fibrosis in hepatitis C: are they ready to avoid liver biopsy?
-
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
…Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated…
-
Letter: APRI and FIB-4 do not correlate with Fibrosure in the evaluation of liver fibrosis in hepatitis C patients.
-
Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
…Three hundred fifty-two patients who had had 2 interpretable liver biopsies…
-
Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
### Objectives Liver fibrosis in chronic hepatitis C is related to sex, age…
-
Defining the Minimum Acceptable Diagnostic Accuracy of Noninvasive Fibrosis Testing in Cirrhosis: A Decision Analytic Modeling Study.
…NITs) compared to liver biopsy (LB) in diagnosing cirrhosis. Our aim was…
-
Assessment of liver fibrosis: noninvasive means.
Liver biopsy, owing to its limitations and risks, is an imperfect gold…
-
Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.
…Fibrotest was determined in 37 children, 45 children had an additional liver…
-
Impact of steatosis and inflammation definitions on the performance of NASH tests.
…We reviewed the landmark studies in metabolic liver disease, sources of the…
-
[Prognosis assessment of alcoholic liver disease: how and why?].
Alcoholic liver disease (ALD) causes more than 5000 deaths per year in…
-
Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.
### Background & Aims Most liver transplant centres have discontinued the practice of protocol…
-
Non-invasive evaluation of liver fibrosis in chronic hepatitis C.
…Liver fibrosis and its end-point cirrhosis are the main causes of…
-
Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…from liver biopsies. ### Results Data from 182 patients with baseline liver biopsy…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
### Background Progression of recurrent hepatitis C is accelerated in liver transplant recipients…
-
Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
…The AUROC curve comparing the Fibrotest with liver biopsy with a cutoff…
-
Biomarkers of liver fibrosis.
Liver biopsy, due to its limitations and risks, is an imperfect gold…
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Liver biopsy: the best standard...when everything else fails.
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease.
…The use of AshTest may reduce the need for liver biopsy, and…
-
A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.
### Background & Aims Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease associated with…
-
Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to…
-
Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
…In Burkina Faso, liver biopsy (LB) remains the "gold standard" method for…
-
Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
Background Non-invasive methods for assessing liver fibrosis are increasingly used as…
-
Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…management of patients with chronic liver disease. Non-invasive tests (NITs) have…
-
The use of enzyme results for liver fibrosis evaluation neccessitates standardization.
-
PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
…In multivariate analysis, the predictive variables for advanced liver fibrosis were age…
-
Evaluation of liver stiffness measurement by fibroscan as compared to liver biopsy for assessment of hepatic fibrosis in children with chronic hepatitis C.
The study evaluated liver stiffness measurement (LSM) using non-invasive transient elastography…
-
Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
…The impact of treatment with ADV vs placebo was assessed on liver…
-
FIB-4: a simple, inexpensive and accurate marker of fibrosis in HCV-infected patients.
-
The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
…decreases the need for a liver biopsy. Twenty-five children with naïve…
-
Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
To assess the accuracy of the noninvasive tools, fibrotest (FT) and liver…
-
Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
…nonalcoholic fatty liver disease (NAFLD) should be evaluated for liver fibrosis. However…
-
Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
### Background An accurate diagnosis of hepatitis C virus (HCV)-related liver lesions…
-
FibroMAX: towards a new universal biomarker of liver disease?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
-
Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.
### Background Blood tests of liver injury are less well validated in non…
-
Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
…Based on these results, the use of the biochemical markers of liver…
-
Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.
Patients infected with hepatitis C virus (HCV) have differing levels of liver…
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
…primary liver cancer, variceal bleeding, or decompensation (ascites, encephalopathy, or jaundice). ### Methods…
-
Reproducibility of blood tests of liver fibrosis in clinical practice.
### Objectives To evaluate the inter-laboratory reproducibility of blood test for liver…
-
Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
-
Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
…test for diagnosing fibrosis or cirrhosis in patients with chronic hepatitis C…
-
Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…AshTest is an appropriate non-invasive alternative to transjugular liver biopsy.
-
Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis.
Nonalcoholic steatohepatitis (NASH) can lead to complications such as liver failure, cirrhosis…
-
Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection.
…as a noninvasive alternative to liver biopsy (LB), but there are few…
-
Alpha-2-macroglobulin and hepatic fibrosis. Diagnostic interest.
…different histological stages of alcoholic liver disease to assess if the A2M…
-
Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…We also examined the inter-observer variations after independent review of liver…
-
Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
### Background & Aims Liver stiffness (LS) measurement using transient elastography and the FibroTest…
-
Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…CAP was significantly correlated with SteatoTest, Fatty Liver Index (FLI), percentage of…
-
FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
-
Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication
…of non-invasive biomarkers in liver fibrosis. A scoring system has been…
-
Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
### Background Assessment of fibrosis progression in chronic liver disease relies upon non…
-
Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
…Few studies investigated noninvasive markers of liver fibrosis in hepatitis C virus…
-
Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
…these findings in women and in people with other chronic liver diseases.
-
Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.
…About 1/3 of carriers have moderate to severe liver fibrosis and…
-
Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
Nonalcoholic fatty liver disease (NAFLD) is independently linked to cardiometabolic morbidity and…
-
Biomarkers for liver disease in urea cycle disorders.
…Liver disease in UCDs may be associated with hepatic inflammation, hepatic fibrosis…
-
Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
### Background/Aims Non-invasive markers of liver fibrosis have recently been developed…
-
Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers.
…Since liver biopsy is invasive, expensive and prone to sampling error, several…
-
The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…transferrin (CDT%), is confounded by liver disease severity. The aim was to…
-
The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
…in order to avoid the liver biopsy currently used for selection of…
-
A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.
### Background And Goal International guidelines suggest combining a blood test and liver…
-
Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…We aimed to verify whether monitoring by liver biopsy might be replaced…
-
Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
### Background Liver disease is the third leading cause of mortality in patients…
-
Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
-
Non-invasive fibrosis tests to predict complications in compensated post-hepatitis C cirrhosis.
…patients with compensated cirrhosis: 97 patients who developed liver-related complications such…
-
FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…
-
Usefulness of noninvasive tests in nodular regenerative hyperplasia of the liver.
### Background The only way to diagnose nodular regenerative hyperplasia (NRH) is liver…
-
Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
### Unlabelled Males have strikingly increased risk of advanced liver disease. However, the…
-
Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data.
### Background Liver biopsy is considered as the gold standard for assessing non…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
-
[Biomarkers for liver fibrosis: advances, advantages and disadvantages].
Liver cirrhosis in Mexico is one of the most important causes of…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…We sought to evaluate liver stiffness measurement by FibroScan® (LSM) and two…
-
Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…With reliable diagnosis intervals, liver biopsy can therefore be avoided in all…
-
European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…Liver fat content (assessed using proton magnetic resonance spectroscopy), fatty liver index…
-
An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
…Baseline liver biopsies were evaluated for METAVIR fibrosis by a single pathologist…
-
Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
-
Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
### Aim Of The Study Was to evaluate liver disease severity in children…
-
Evolution of Non-alcoholic Fatty Liver Disease (NAFLD) Biomarkers in Response to Weight Loss 1 Year After Bariatric Surgery-a Post Hoc Analysis of the FibroTest Prospective Study.
…Histological data regarding intraoperative liver biopsy were collected at baseline, clinical, and…
-
Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies.
### Background Liver biopsy and virological end points are standard references for assessing…
-
Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…For the prediction of survival without liver-related death, the areas under…
-
A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication
### Background FibroTest, a noninvasive method of measuring biomarkers of liver fibrosis, is…
-
An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group.
…A panel of 10 pathologists reviewed 363 chronic hepatitis C liver biopsies…
-
GlycoFibroTest is a highly performant liver fibrosis biomarker derived from DNA sequencer-based serum protein glycomics.
Liver fibrosis is currently assessed by liver biopsy, a costly and rather…
-
Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
### Background Liver biopsy is considered as the gold standard for assessing nonalcoholic…
-
Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods.
### Background Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of…
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Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
The diagnostic utilities of ultrasonography (US), fatty liver index (FLI) and an…
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
### Background In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and…
-
FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
### Background Noninvasive markers of liver fibrosis have not been extensively studied in…
-
Hepatitis C virus viremia and low platelet count: a study in a hepatitis B & C endemic area in Taiwan.
### Background & Aims Hepatitis C virus (HCV) infection has been shown to be…
-
Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
### Introduction Nonalcoholic fatty liver disease (NAFLD) is one of the most common…
-
First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy.
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Discordance between biochemical markers of liver activity and fibrosis (Actitest-Fibrotest) and liver biopsy in patients with chronic hepatitis C.
…practice and in comparison with liver biopsy the limitations of two blood…
-
Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
Fontan-associated liver disease (FALD) is a serious complication related to the…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
### Background Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates…
-
Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
### Background Aims Liver biopsy is the gold standard for assessing hepatitis B…
-
Progression of liver fibrosis among injection drug users with chronic hepatitis C.
…Baseline liver biopsies were obtained (1996-1998) on a random sample of…
-
The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
### Background Biopsy is the usual gold standard for liver steatosis assessment. The…
-
Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
…FibroSure; LabCorp, Burlington, USA) and liver stiffness measurement (LSM) by Fibroscan (Echosens…
-
Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
…Serum samples were obtained and liver needle biopsy was performed on the…
-
FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases.
-
Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.
-
[SWE elastography in assessment of liver fibrosis].
Liver fibrosis is a relatively common consequence of chronic liver diseases, especially…
-
Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.
…To evaluate the association between anthropometric measurements and advanced liver disease in…
-
Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients.
### Unlabelled Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and being overweight…
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
…Steatosis was demonstrated in all 5 patients who received liver biopsies during…
-
American Association for the Study of the Liver
-
A simple biological index for detection of alcoholic liver disease in drinkers.
…of cirrhosis was 0% and the probability of normal liver or minimal…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
…competitor as a biomarker of liver fibrosis in comparison with the standard…
-
Biochemical and biophysical assessment of MTX-induced liver fibrosis in psoriasis patients: Fibrotest predicts the presence and Fibroscan predicts the absence of significant liver fibrosis.
…To monitor this serial liver biopsies were performed. The Fibroscan and the…
-
Meta-analyses of FibroTest diagnostic value in chronic liver disease.
### Background FibroTest (FT) is a biomarker of liver fibrosis initially validated in…
-
Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
…thoroughly evaluated in comparison to liver biopsy, especially in clinical practice and…
-
Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
…serum-based assessment of liver fibrosis is still an important diagnostic challenge…
-
Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
…Progressive liver injury is a concern in HIV-infected children exposed to…
-
Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Review
### Background Fibrosis impacts long-term outcomes among patients with nonalcoholic fatty liver…
-
Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
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FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy.
…Methodological quality, the length of liver biopsy specimens, and inclusion of special…
-
Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.
…is the prediction of metabolic liver disease (MLD) by noninvasive tests (NITs…
-
Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
### Background FibroTest has been validated for the diagnosis of liver fibrosis in…
-
Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
…HCV-related liver disease. ### Background Males have strikingly greater cirrhosis risk across…
-
Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
…oral glucose tolerance test, a liver proton magnetic resonance spectroscopy (^1^H…
-
[The prediction and validation of liver fibrosis by a noninvasive model and validation in patients with chronic hepatitis B].
### Objective To develop a simple model for the noninvasive diagnosis of liver…
-
[FibroTest-ActiTest for predicting liver fibrosis and inflammatory activity in Chinese patients with chronic hepatitis B]. Key publication
…ActiTest (FT-AT) in predicting liver fibrosis and inflammatory activity in patients…
-
Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
-
Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.
-
Applicability and variability of liver stiffness measurements according to probe position.
### Aim To investigate the liver stiffness measurement (LSM) applicability and variability with…
-
Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
…Children present severe fatty liver disease with early cirrhosis. Before enzyme replacement…
-
Hepatitis B virus genotype G and liver fibrosis progression in chronic hepatitis B and human immunodeficiency virus coinfection.
…In the 43 (27.2%) patients with F3-F4 baseline liver fibrosis…
-
FibroTest is effective in patients with normal transaminases, when accuracy is standardized on fibrosis stage prevalence.
-
Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
Liver stiffness was measured by transient elastography (FibroScan) in 228 consecutive patients…
-
Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
### Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to…
-
Poynard T, Ratziu V, Imbert-Bismut F, Munteanu M
-
Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
-
Analytical variability of the Fibrotest proteins.
…hepatitis C infection who underwent liver biopsy. We compared measurements of haptoglobin…
-
FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest.
…Using these ranges, 72.8% of the 847 liver biopsies were correctly…
-
A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease.
…Biochemical markers for liver fibrosis (FibroTest) and necroinflammatory features (ActiTest) are an…
-
Poynard T, Imbert-Bismut F, Ratziu V, Myers RP, Di Martino V, Thabut D, Moussalli J, Benhamou Y
-
ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure.
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
-
Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered the gold standard for assessing histologic lesions…
-
Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
…being developed as alternatives to liver biopsy in patients with chronic hepatitis…
-
Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…
-
Diagnostic value of FibroTest with normal serum aminotransferases.
-
Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
### Background The area under the ROC curve (AUC) is widely used as…
-
Reproducibility of non-invasive fibrosis biomarkers, FibroMeter and FibroTest, could be improved by respecting the analytical standardizations.
-
External validation of FibroIndex.
-
FibroTest has better diagnostic and prognostic values than the aspartate aminotransferase-to-platelet ratio index in patients with chronic hepatitis C.
-
Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
-
Noninvasive prediction of fibrosis in patients with chronic hepatitis C.
-
Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.
-
Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
…All patients in the cohort except 1 were managed without a liver…
-
A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers.
In therapy with standard interferon and ribavirin, five independent risk factors (RF…
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Biopsy as well as FibroTest/Fibrosure is suboptimal for discriminating intermediate fibrosis stages in patients with chronic hepatitis B.
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
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The risks of changing the rules for previously validated biomarkers and using the same patients several times. Response letter to Calès et al. Gastroenterol Clin Biol 2008;32:1050-60: "Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests".
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Role of genotype G hepatitis B virus mixed infection on the progression of hepatic fibrosis in HIV positive patients over 5 years of follow-up.
…The dynamic of liver disease in co-infected patients is important to…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
…2-diabetes (T2D), obesity, and liver fibrosis (resmetirom) announce the widespread use…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
…CHB and its consequences on liver injury compared with CHC and NAFLD…
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Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.
### Background And Aims The European Association for the Study of the Liver…
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Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…We aimed to compare blood fibrosis tests and liver stiffness measurement (LSM…
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Glycogenic hepatopathy.
…GH may be diagnosed also after elevated liver enzymes in routine blood…
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Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.
…infected patients with liver disease documented by liver biopsy, matched with HIV…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis.
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.
In patients with non-alcoholic fatty liver disease (NAFLD) with or without…
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Commentary: prognostication of chronic hepatitis B - are Fibrotest and Fibroscan the final answers? Authors' reply.
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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
Chronic Obstructive Pulmonary Disease (COPD) and Non-Alcoholic Fatty Liver Disease (NAFLD…
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[Diagnostic value of FibroTest for liver fibrosis in patients with chronic hepatitis B].
### Objective To determine the diagnostic value of FibroTest (FT) for liver fibrosis…
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Effective use of FibroTest to generate decision trees in hepatitis C.
…chronic hepatitis C without a liver biopsy. The FibroTest attributes of age…
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Implementing non-invasive markers for liver fibrosis in clinical practice.
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Screening studies of transient elastography and FibroTest in the general population.
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Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
…Histological features were assessed invasively by liver biopsy and noninvasively using FibroTest…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
…Investigations included assessment of abdominal ultrasonography, liver biopsy, calculation of body mass…
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[The scope of clinical applications of noninvasive methods for the assessment of liver fibrosis results of orginial studies in a multi-field hospital].
…the diagnosis of hepatic fibrosis in patients with chronic viral liver infection.
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
…These consisted of 29 healthy volunteers and 35 patients with chronic liver…
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Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
…Such discordance is of little clinical consequence for liver fibrosis evaluation in…
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…Evaluation of liver fat was performed using four noninvasive methods: the SteatoTest…
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Screening studies of transient elastography and FibroTest in the general population - Authors' reply.
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[Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura].
…to serious complications, such as cirrhosis and hepato-cellular carcinoma (HCC). HBV…
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…Assessing liver fibrosis is crucial for managing autoimmune hepatitis (AIH), yet reliance…
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Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry.
### Background Hepatic and renal dysfunction have been observed in survivors of the…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
…better biomarkers of drug-induced-liver-injury (DILI). ### Aims We aimed to…
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Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions.
### Background Elevation of liver enzymes in rheumatoid arthritis patients treated with tocilizumab…
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Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis.
…Serum levels of 25(OH)D3 were also significantly correlated with liver…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.
…for the diagnostic of metabolic liver disease in patients with type-2…
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FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
### Background & Aims EPIC-3 is a prospective, international study that has demonstrated…
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Factors to improve the management of hepatitis C in drug users: an observational study in an addiction centre.
…In 2002, 6 patients had liver fibrosis assessment at hospital facilities, 4…
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes.
…the prediction of non-alcoholic liver disease by non-invasive blood tests…
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Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
### Background Mortality related to complications of cirrhosis is increasing in patients with…
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Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
…Fatty liver was diagnosed with abdominal ultrasound and liver steatosis was quantified…
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Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy.
### Objectives The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI…
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Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
…liver injury. ### Conclusion A number of non-invasive markers of liver damage…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
…By multivariate analysis, independent factors for liver steatosis were, as expected, triglyceride…
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Intermethod calibration of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) results: application to Fibrotest and Actitest scores.
…liver fibrosis or necro-inflammatory lesions as an alternative to liver biopsy…
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Validation of the Performance of A1HPV6, a Triage Blood Test for the Early Diagnosis and Prognosis of SARS-CoV-2 Infection.
### Background And Aims Apolipoprotein A1 (A1) and haptoglobin (HP) serum levels are…
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[Results transferability on RXL, ARX, X-Pand, BN2 (Dade Behring) and modular DP (Roche Diagnostics) analysers: application to component assays of fibrotest and Actitest].
The follow up of patients with chronic liver diseases and the data…
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[The value of noninvasive serological markers in hepatitis B].
Bloodless methods (serological and imaging) for evaluating hepatic fibrosis constitute a good…
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Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
…AT), are an alternative to liver biopsy in patients with chronic hepatitis…
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Silymarin in non alcoholic fatty liver disease.
…The brightness of liver echography texture (hepatorenal ratio brightness) was also defined…
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Ministère des Affaires Sociales et de la Santé Key publication
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