Scientific publications for BioPredictive non-invasive diagnostics
Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.
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Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C.
…We evaluated their diagnostic accuracy, and how to increase it, for the…
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Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.
### Background The reliable diagnosis rate of diagnostic tests is provided by their…
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods.
…However, several non-invasive diagnostic strategies have been proposed as potential diagnostic…
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A new combination of blood test and fibroscan for accurate non-invasive diagnosis of liver fibrosis stages in chronic hepatitis C.
…Fibroscan and FibroMeter were the independent predictors of different diagnostic targets of…
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Optimization and robustness of blood tests for liver fibrosis and cirrhosis.
### Objectives To optimize the performance and feasibility of fibrosis blood tests and…
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Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.
…Successive SAFE had a significantly (P < 10(-3) ) lower diagnostic accuracy (87…
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…The combination of APRI or FIB-4 with Fibrometer increased the diagnostic…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…Within these populations, the diagnostic target, significant fibrosis (Metavir F > or = 2…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis.
…The analysis also aimed to compare the diagnostic accuracy of transient elastography…
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Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests.
…hepatitis C. ### Results Using the diagnostic limits provided by fibrosis stage scales…
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Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
…The aim was to summarize the diagnostic value of these tests from…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…using the Quality Assessment of Diagnostic Accuracy Studies-2. ### Results In total…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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Prospective evaluation of FibroTest®, FibroMeter®, and HepaScore® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C.
…Their diagnostic accuracy is less documented in hepatitis B. The aim of…
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Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.
…Our aim was to increase the diagnostic performance of non-invasive markers…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
…new scores could improve the diagnostic accuracy and reduce liver biopsy requirement…
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Meta-analyses of FibroTest diagnostic value in chronic liver disease.
…The aim was to test two hypotheses, one, that the FT diagnostic…
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
The aim of this study was to evaluate the diagnostic values of…
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Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.
…However, to date, diagnostic performances of Enhanced Liver Fibrosis (ELF) test, which…
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Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.
…Moreover, the performance should be reported with different diagnostic targets.
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Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.
…This study was designed to evaluate the diagnostic value of the four…
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The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy.
…The questionnaire for quality assessment of diagnostic accuracy studies (QUADAS) was used…
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Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication
…The aim of the study was to compare the diagnostic and prognostic…
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FibroStic: a large confirmatory study for non-invasive biomarkers accuracy, if correctly interpreted.
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…We aimed to validate the diagnostic utility of TE for liver fibrosis…
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Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
…However, the sensitivity, specificity and diagnostic accuracy in evaluating liver fibrosis of…
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The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).
The aim of this study was to evaluate the diagnostic usefulness of…
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…This study evaluates the diagnostic performance of FibroTest-Actitest, transient elastography, and…
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…This study aims, prospectively, to confirm the diagnostic value of PGAA and…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication
This review summarizes the methodological aspects of the interpretation of non-invasive…
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis.
…We aimed to systematically review studies describing the diagnostic accuracy of FT…
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Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.
### Background And Aims Diagnostic values of FibroTest (FT) for hepatic fibrosis have…
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Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
…The diagnostic accuracy (AUROC) for the diagnosis of large oesophageal varices was…
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Guidelines for the diagnosis of uncomplicated cirrhosis.
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Biomarkers of liver fibrosis.
…The mean diagnostic value for the diagnosis of advanced fibrosis assessed using…
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Comparison of FibroTest-ActiTest with histopathology in demonstrating fibrosis and necroinflammatory activity in chronic hepatitis B and C.
### Aims FibroTest and ActiTest are noninvasive tests used in determining the level…
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Systematic review and meta-analysis of the diagnostic accuracy of fibrosis marker panels in patients with HIV/hepatitis C coinfection.
…CI 0.78-86) and diagnostic odds ratio was 7.8 (5…
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Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.
…optimized combination algorithms to improve diagnostic accuracy. ### Methods The cohort included 467…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication
…For diagnostic value, the main endpoint was the FT area under the…
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Correlation between liver biopsy and fibrotest in the evaluation of hepatic fibrosis in patients with chronic hepatitis C.
### Aim To assess the diagnostic value of Fibrotest in comparison with liver…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…We aimed to evaluate the diagnostic efficiency of non-invasive serum biomarkers…
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Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C.
…The aim of this study was to compare the diagnostic performance of…
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.
### Background And Aims The FibroTest (FT) demonstrated excellent diagnostic performance in the…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection.
…results, while disadvantages include lower diagnostic accuracy in intermediate disease stages and…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers.
…However, diagnostic accuracy can be improved by combining blood biomarkers. NAFLD fibrosis…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
…explain any differences, and adapt diagnostic algorithms for clinical practice accordingly. ### Methods…
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FibroMAX: towards a new universal biomarker of liver disease?
Among the noninvasive alternatives to liver biopsy, several studies have demonstrated the…
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Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C.
### Background Non-invasive tests have been constructed and evaluated mainly for binary…
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Liver fibrosis markers in alcoholic liver disease.
…There are only a few studies evaluating the diagnostic and prognostic values…
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Assessment of liver fibrosis: noninvasive means.
…For FibroTest, the mean diagnostic value for the diagnosis of advanced fibrosis…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.
…Secondary aims were to assess the diagnostic accuracy of ELF for significant…
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Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.
…The diagnostic value of FT (F2F3F4 vs. F0F1) was assessed by an…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.
…data. ### Aim To investigate the diagnostic performance of three fibrosis noninvasive tests…
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.
…cirrhosis. ### Purpose To evaluate the diagnostic accuracy of blood tests to identify…
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Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.
…42.6 +/- 11.3) with CHB undergoing diagnostic liver biopsy were included…
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Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis.
The limitations of liver biopsy (invasive procedure, sampling errors, inter-observer variability…
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Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study.
…biopsies could not be interpreted. Diagnostic accuracies were assessed by receiver operating…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.
### Background Blood tests of liver injury are less well validated in non…
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The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
### Background Liver biopsy is thought mandatory for management of patients with hepatitis…
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Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes.
…the ROC curve. ### Results The diagnostic performance of each component of the…
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Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
### Objective The aim of our study was to assess the diagnostic performance…
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Combination of fibrosis tests: sequential or synchronous?
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The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience.
### Aim To assess the diagnostic value of FibroTest to discriminate between insignificant…
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease.
### Background/Aims The aim was to identify a panel of biomarkers (AshTest…
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Diagnostic accuracy of the fibrotest in hemodialysis and renal transplant patients with chronic hepatitis C virus.
…The aim of this study was to assess the diagnostic accuracy of…
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Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial.
…The aim of this study was to retrospectively assess the diagnostic value…
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A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation.
…imaging technique may be the better non invasive diagnostic method in future.
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Noninvasive Assessment of Liver Fibrosis.
…an attractive approach that increases diagnostic performance and limits the drawback of…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data.
…with severe obesity, a significant diagnostic performance of FibroTest, SteatoTest and ActiTest…
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Noninvasive diagnosis in alcohol-related liver disease. Review
### Background Alcohol-related liver disease (ALD) represents a major cause of death…
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[The diagnostic value of non-invasive biochemical biomarkers in alcohol abuse].
…The aim of the study was to evaluate the diagnostic usefulness of…
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Biopsy as well as FibroTest/Fibrosure is suboptimal for discriminating intermediate fibrosis stages in patients with chronic hepatitis B.
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease.
…As described in other liver disease, the diagnostic accuracy of such tests…
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
The aim was to assess the utility of FibroTest-ActiTest (FT-AT…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis.
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Hepatitis B: are non-invasive markers of liver fibrosis reliable?
Liver biopsy, which was traditionally considered to be the gold standard for…
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
…The aim of this study was to determine the diagnostic utility of…
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…decisions. ### Objectives To evaluate the diagnostic accuracy, cost-effectiveness, and effect on…
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
A serum biomarker (FibroTest; Biopredictive, Paris, France; FibroSure; LabCorp, Burlington, USA) and…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
### Purpose To compare the diagnostic performance of acoustic radiation force impulse (ARFI…
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
…as an estimate of the diagnostic value for fibrosis markers. Biopsy length…
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Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
### Background Progression of recurrent hepatitis C is accelerated in liver transplant recipients…
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Diagnosis of fibrosis and cirrhosis. Liver biopsy is not always necessary.
…This review examines available literature on the use and diagnostic performance of…
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…The diagnostic accuracy of FLI for steatosis > 5%, as predicted by SteatoTest…
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Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
…The diagnostic performance of these tools for the detection of CFLD (defined…
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A novel panel of blood markers to assess the degree of liver fibrosis.
…Whereas the Fibrometer has a high diagnostic accuracy for clinically significant fibrosis…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…in all patients. ### Results The diagnostic accuracy of FS was 0.89…
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Severity of Fontan-Associated Liver Disease Correlates with Fontan Hemodynamics.
Fontan-palliated patients are at risk for the development of Fontan-associated…
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Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.
…This ANRS HCEP-23 study compared the diagnostic accuracy of nine blood…
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Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis.
…can be performed with comparable diagnostic accuracy for the non-invasive staging…
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SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
…The diagnostic accuracy of SAFE biopsy versus histology, which is the gold…
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Validation of the Performance of A1HPV6, a Triage Blood Test for the Early Diagnosis and Prognosis of SARS-CoV-2 Infection.
…The primary diagnostic endpoint was the area under the receiver operating characteristic…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.
…The primary aim was to compare the diagnostic performances of FibroTest in…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…Conclusion These results confirmed the diagnostic performance of AshTest in cirrhotic patients…
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
…The aim of this study was to determine the diagnostic utility of…
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Diagnostic algorithms for liver fibrosis in hepatitis C: are they ready to avoid liver biopsy?
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
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Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.
…aminotrasferase (EALT) who underwent a diagnostic liver biopsy were evaluated for AST…
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B.
…studies that directly compared the diagnostic accuracy of FibroTest, aspartate aminotransferase-platelet…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
### Background Biopsy is the usual gold standard for liver steatosis assessment. The…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Liver biopsy was the main diagnostic tool for 46.2% of the…
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FibroScan and FibroTest to assess liver fibrosis in HCV with normal aminotransferases.
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
…The diagnostic values in the group of good quality biopsy (n=41…
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.
…biopsy failure is >7 times more common than diagnostic failure of markers.
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
### Background & Aims The aim of this study was to determine the diagnostic…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis.
…to date has addressed the diagnostic utility of these techniques in the…
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Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.
…Using the Obuchowski Index, Coopscore© shows higher diagnostic performances than for Fibrometer…
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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.
…25). ### Results TE had the best diagnostic accuracy for detection of cirrhosis…
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Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
### Introduction Nonalcoholic fatty liver disease (NAFLD) is one of the most common…
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Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.
…This study compares the concurrent diagnostic performances of LSM and FibroTest using…
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Non-invasive diagnosis and follow-up of portal hypertension.
Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis…
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Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
### Background And Aims Gilbert syndrome (GS) is genotypically predetermined by UGT1A1*28…
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Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
…serum-based assessment of liver fibrosis is still an important diagnostic challenge…
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Relationship between the Fibrotest and portal hypertension in patients with liver disease.
### Background The best technique to estimate portal hypertension (PHT) is to measure…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
### Aims And Methods Several serum biomarkers such as FibroTest, aspartate transaminase-platelet…
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Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.
### Background Liver biopsy is an imperfect gold standard for assessing the disease…
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Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters?
…Further studies are required to compare the diagnostic performance of different non…
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
### Background Liver biopsy is considered the gold standard for assessing histologic lesions…
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Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver-prognosis in chronic hepatitis C.
…shown their combination significantly improves diagnostic accuracy. ### Aim To compare the prognostic…
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
### Background & Aims Liver fibrosis stage is traditionally assessed with biopsy, an imperfect…
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
### Background FibroTest(®) (FT), and liver stiffness measurement (LSM) are the most validated…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy.
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
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Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.
### Unlabelled Liver biopsy is the gold standard for assessing fibrosis but has…
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Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.
### Background/Aims The aim of this study was to compare the performance…
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Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease.
…The diagnostic accuracy expressed as areas under ROC curves was 0.84…
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…The diagnostic performance of these screening strategies was statistically superior to the…
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Noninvasive evaluation of NAFLD.
A common clinical concern in patients with NAFLD is whether they have…
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Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
### Background And Aims Transient elastography (FibroScan; Echosens, Paris, France) is a novel…
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Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.
### Background Preliminary data suggest that performance of non-invasive markers for liver…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests. Key publication
…alcohol abuse patients, to determine diagnostic liver stiffness cut-off values and…
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Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.
### Aim To investigate the diagnostic accuracy of acoustic radiation force impulse (ARFI…
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Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics.
We applied our 'clinical glycomics' technology, based on DNA sequencer/fragment analyzers…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
### Background & Aims Real-time shear wave elastography (SWE) is a new two…
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Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitis.
…or HBV infections, but their diagnostic value for predicting severe liver disease…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…was shown to have acceptable diagnostic accuracy. New serum biomarkers are under…
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Spleen stiffness measurement by transient elastography to diagnose portal hypertension in children.
…and compare data on its diagnostic use with established markers of liver…
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The non-invasive assessment of hepatic fibrosis.
Hepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis…
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[Prognosis assessment of alcoholic liver disease: how and why?].
Alcoholic liver disease (ALD) causes more than 5000 deaths per year in…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…whether biopsy has a lower diagnostic performance for fibrosis stage F2 (few…
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Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
…The aim was to determine the diagnostic utility of noninvasive serum markers…
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Altered serum N-glycomics in chronic hepatitis B patients.
…The diagnostic power of serum glycan marker (GlycoFibroTest) [area under the curve…
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Alpha-2-macroglobulin and hepatic fibrosis. Diagnostic interest.
…In 525 alcoholic patients, we have demonstrated the independent diagnostic value of…
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
### Background Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold…
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Defining the Minimum Acceptable Diagnostic Accuracy of Noninvasive Fibrosis Testing in Cirrhosis: A Decision Analytic Modeling Study.
…Decision analytic models were used to determine the minimum acceptable diagnostic accuracy…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
### Objectives To evaluate the diagnostic performance of seven non-invasive tests (NITs…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.
Patients with HIV have a proclivity to develop liver fibrosis, especially when…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
### Background In recent years noninvasive methods have been evaluated for the assessment…
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Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…We evaluated eight blood tests and FibroScan in a cross-sectional diagnostic…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
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Reproducibility of non-invasive fibrosis biomarkers, FibroMeter and FibroTest, could be improved by respecting the analytical standardizations.
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
### Background And Aims Real-time shear wave elastography (2D-SWE) is a…
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
BACKGROUND: Biochemical marker combinations, including alpha2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl…
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Non-invasive assessment of liver fibrosis: are we ready?
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
### Background This prospective, monocentric study was designed to assess the efficacy of…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
### Background And Aim The validity of biomarkers of excessive alcohol drinking (EAD…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure.
### Background ActiTest (AT) is a biomarker of liver necro-inflammatory histological activity…
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First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy.
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
### Background Hepatitis C virus (HCV) is a major cause of chronic hepatitis…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
**Background/Objectives:** Bariatric surgery (BS), drugs approved for type-2-diabetes (T2D…
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
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An evaluation of the potential cost-effectiveness of non-invasive testing strategies in the diagnosis of significant liver fibrosis.
…The primary outcomes were sensitivity, specificity, diagnostic accuracy (true positive + true negatives…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
### Background & Aims Non-invasive assessment of liver fibrosis is a challenging area…
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Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.
### Background Liver stiffness and non-invasive tests predict overall survival in chronic…
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…The diagnostic performance of these tests was assessed using receiver operating characteristic…
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Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.
### Background & Aims Liver stiffness (LS) measurement using transient elastography and the FibroTest…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
### Background HIV-monoinfected individuals are at high risk of nonalcoholic fatty liver…
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Non-invasive markers for hepatic fibrosis.
…The rate of adoption of non-invasive diagnostic tests for liver fibrosis…
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Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.
### Background Patients with cystic fibrosis (CF) have a relevant morbidity and mortality…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
Transient elastography (TE) is a noninvasive technique to evaluate liver fibrosis. We…
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Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.
### Background Liver fibrosis, now assessed by liver biopsy or using non-invasive…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
…reliable. ### Aim To assess the diagnostic performance of the FibroSURE (FS) index…
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Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study.
### Background And Aims Primary prevention of variceal bleeding with beta-blockers improves…
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Prevalence of liver fibrosis and cirrhosis in 699 Moroccan patients with chronic hepatitis C.
…VITROS® Chemistry System Ortho Clinical Diagnostic. A 699 patients with CHC were…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.
The assessment of the fibrotic evolution of chronic hepatitis has always been…
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
### Background Two widely used biomarkers of fibrosis, FibroTest and liver stiffness measurement…
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The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women.
### Unlabelled Introduction and aim. Given that early identification of non-alcoholic fatty…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
### Background And Aim Significant hepatic fibrosis is prognostic of liver morbidity and…
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[Diagnostic value of FibroTest for liver fibrosis in patients with chronic hepatitis B].
### Objective To determine the diagnostic value of FibroTest (FT) for liver fibrosis…
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[FibroTest-ActiTest for predicting liver fibrosis and inflammatory activity in Chinese patients with chronic hepatitis B]. Key publication
### Objective To confirm the diagnostic value of FibroTest-ActiTest (FT-AT) in…
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Fibromax-based nonalcoholic fatty liver disease in chronic obstructive pulmonary disease patients with obstructive sleep apnea: Methodological considerations.
…had OSA, basing the NAFLD diagnostic on three circulating biomarker-based liver…
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
As of 2016, there is no evidence-based pathway to stratify the…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review.
Haemophilia is an entity, wherein the HCV infection rate is greater than…
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Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
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Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
…Conclusions This study supports the diagnostic value of the Coospcore^©^ in fibrosis…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors.
Combinations of tests comprising alpha2-macroglobulin, haptoglobin, apolipoprotein Al, gamma-glutamyltransferase, total…
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The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.
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Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.
### Objectives Combining noninvasive tests increases diagnostic accuracy for staging liver fibrosis in…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.
In patients with non-alcoholic fatty liver disease (NAFLD) with or without…
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Discordance between biochemical markers of liver activity and fibrosis (Actitest-Fibrotest) and liver biopsy in patients with chronic hepatitis C.
…Receiver operating characteristics (ROC) curves were used to assess the diagnostic value…
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
…as an estimate of the diagnostic value for fibrosis markers. Whether there…
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Reproducibility of blood tests of liver fibrosis in clinical practice.
### Objectives To evaluate the inter-laboratory reproducibility of blood test for liver…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
### Background Non invasive methods for fibrosis evaluation remain to be validated longitudinally…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease.
### Background Although the FibroTest has been validated as a biomarker to determine…
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
### Aims To evaluate the application of the recently proposed recommendations by the…
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Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy.
### Objectives The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI…
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
…P < 0.001), indicating greater diagnostic value. The addition of the latter…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.
### Background One of the unmet needs in patients with metabolic risks is…
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Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
The diagnostic utilities of ultrasonography (US), fatty liver index (FLI) and an…
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
### Background The aspartate aminotransferase platelet ratio index (APRI) is a validated, non…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
### Objectives Staging liver fibrosis in chronic viral hepatitis C (HCV) patients is…
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Non-invasive diagnosis and follow-up of chronic infection with Hepatitis C Virus.
…considerably with developments in screening, diagnostic procedures to evaluate liver fibrosis and…
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An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.
Noninvasive markers that accurately follow changes in fibrosis may provide alternatives to…
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Analytical variability of the Fibrotest proteins.
### Objectives The analytical variability of the Fibrotest (FT) parameters raises the issue…
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
…The diagnostic values of the indices were compared using receiver operating characteristic…
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Poynard T, Ratziu V, Imbert-Bismut F, Munteanu M
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FibroTest is effective in patients with normal transaminases, when accuracy is standardized on fibrosis stage prevalence.
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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
…the general population and its diagnostic performance for the Covid-19. ### Methods…
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FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.
…with a potential for high diagnostic accuracy in Asians with chronic HCV.
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
Liver fibrosis and activity indexes were validated in patients infected by hepatitis…
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Poynard T, Imbert-Bismut F, Ratziu V, Myers RP, Di Martino V, Thabut D, Moussalli J, Benhamou Y
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Performance of the FibroTest cannot be accurately estimated in nine paediatric patients with advanced fibrosis.
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Noninvasive assessment of portal hypertension in patients with cirrhosis.
Severe portal hypertension is responsible for complications and death. Although measurement of…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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[Alpha 2 macroglobulin immunoturbidimetric assays (DakoCytomation reagents) on Roche Diagnostic analysers (Modular P, Cobas Integra). Application to FibroTest-Actic-Test].
### Background Alpha2Macroglobulin (A2M) measure showed a revival since it was introduced into…
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The role of the non-invasive serum marker FibroTest-ActiTest in the prediction of histological stage of fibrosis and activity in children with naïve chronic hepatitis B infection.
The aim of this study was to investigate whether the non-invasive…
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Evaluation of FibroTest-ActiTest in children with chronic hepatitis C virus infection.
FibroTest-ActiTest (FT-AT) has been validated in adults with chronic hepatitis…
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Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.
### Background/Aims To compare non-invasive biological liver fibrosis scores, as alternatives…
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Liver biopsy: the best standard...when everything else fails.
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
### Background & Aims Patients with diabetes are at risk for nonalcoholic fatty liver…
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Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.
The aim of this study was to compare the results of nine…
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Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.
### Background And Aims Hepatobiliary disorders, associated either with extraintestinal manifestations or with…
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Fibrotest-Actitest: the biochemical marker of liver fibrosis--the Israeli experience.
### Background The Fibrotest-Actitest is a six-parameter scoring system that allows…
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Interferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.
### Background & Objectives One of the multiple factors contributing to virological response in…
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Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.
…However, diagnostic markers for this condition are limited. We hypothesized that specific…
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The new paradigm of hepatitis C therapy: integration of oral therapies into best practices.
Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C…
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
### Objectives Liver fibrosis in chronic hepatitis C is related to sex, age…
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Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.
### Background Steatosis is common in patients with hepatitis C virus (HCV) infection…
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV.
### Background & Aims The Liver Cancer Risk test algorithm (LCR1-LCR2) is a…
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Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.
…We aimed to evaluate the diagnostic accuracy of this algorithm in nonalcoholic…
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A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.
…LSM) in at least 1 diagnostic target in all etiologies, except in…
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[SWE elastography in assessment of liver fibrosis].
…Elastography is a new diagnostic tool that aims to evaluate stiffness of…
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Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
Fibromax is a diagnostic tool composed of the combination of 4 non…
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[The prediction and validation of liver fibrosis by a noninvasive model and validation in patients with chronic hepatitis B].
…The model had a high level of diagnostic value in patients with…
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Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.
### Background & Aims Liver stiffness can be measured noninvasively to assess liver fibrosis…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
### Background Performance of non-invasive fibrosis biomarkers may be influenced by aetiology…
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An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication
…It reviews the epidemiology of hepatitis C in Canada, preferred diagnostic testing…
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Cost effectiveness of fibrosis assessment prior to treatment for chronic hepatitis C patients.
### Background And Aims Chronic hepatitis C (HCV) is a liver disease affecting…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
### Introduction Recently, a study showed that Controlled Attenuation Parameter (CAP), evaluated with…
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Diagnostic value of FibroTest with normal serum aminotransferases.
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The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.
### Background The Fib-4 index is a simple and inexpensive biomarker to…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
### Background There is a clear need for better biomarkers of drug-induced…
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
### Background And Aim One of the unmet needs in subjects with metabolic…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
### Background FibroTest and elastography have been validated as biomarkers of liver fibrosis…
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Effective use of FibroTest to generate decision trees in hepatitis C.
### Aim To assess the usefulness of FibroTest to forecast scores by constructing…
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
### Background The combination of transaminases (ALT), biopsy, HBeAg and viral load have…
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Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
Serum bile acids (SBAs) are commonly elevated in cholestatic liver diseases, but…
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Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: time for new guidelines?
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Evaluation of FibroTest inter-laboratory variations requires standardization on analytical systems and should not be mixed with underpowered histological validation.
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
### Importance The long-term implications of hepatotoxic effects in patients with psoriasis…
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies.
### Background Liver biopsy and virological end points are standard references for assessing…
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[Biomarkers for liver fibrosis: advances, advantages and disadvantages].
…efficient and reliable enough for diagnostic use. In this paper, we describe…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients.
### Background Hepatic fibrosis is highly prevalent in individuals with Fontan circulation. FibroSure…
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Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.
### Objective Transient elastography (FibroScan) is a novel, noninvasive, rapid bedside method to…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
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Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.
### Objective Studies have shown that patients with failing Fontan circulation may develop…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
### Background Effective antiviral treatment (direct-acting antiviral agents (DAAs)), the requirement for…
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Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
### Background Nocturnal hypoxia, the hallmark of OSA, is a potential contributing factor…
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[Results transferability on RXL, ARX, X-Pand, BN2 (Dade Behring) and modular DP (Roche Diagnostics) analysers: application to component assays of fibrotest and Actitest].
The follow up of patients with chronic liver diseases and the data…
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B.
### Background And Aims The liver cancer risk test (LCR1-LCR2) is a…
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Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.
### Objectives : Progressive liver injury is a concern in HIV-infected children exposed…
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FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.
### Background Noninvasive markers of liver fibrosis have not been extensively studied in…
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Stage of liver fibrosis in patients with congenital bleeding disorders and infected with hepatitis C virus.
### Introduction Hepatitis C virus (HCV) is the major cause of chronic liver…
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Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.
Non-invasive modalities to estimate fibrosis stage are desirable in hepatitis C…
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Methotrexate in psoriasis: a systematic review of treatment modalities, incidence, risk factors and monitoring of liver toxicity.
### Background/Aim To define practical use and to specify the ideal method…
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Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.
…The aim of this study was to assess the diagnostic accuracy of…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
### Background No blood test has been shown to be effective in the…
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Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
Retrospective studies suggest that coffee consumption may exert beneficial effects in patients…
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Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
### Background And Aim Mortality of alcohol-related liver disease (ArLD) is increasing…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
The course of hepatitis C virus (HCV) infection carriers with normal/near…
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Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.
…and no reliable non-invasive diagnostic approach is available to discriminate between…
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Optimal correlation between different instruments for Fibrotest-Actitest protein measurement in patients with chronic hepatitis C.
### Objectives Combination of alpha 2-macroglobulin, haptoglobin, apolipoprotein-A1, gamma-glutamyl transpeptidase…
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Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
### Background Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly…
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FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy.
…However, the diagnostic accuracy of both measures was associated with the prevalence…
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Acoustic Radiation Force Impulse Imaging for Diagnosis and Monitoring of Liver Fibrosis in Patients with Hepatitis C: A review of diagnostic accuracy, clinical effectiveness,…
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FibroTest is an independent predictor of virologic response in chronic hepatitis C patients retreated with pegylated interferon alfa-2b and ribavirin in the EPIC³ program.
### Background & Aims EPIC-3 is a prospective, international study that has demonstrated…
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Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.
### Background Non-invasive liver fibrosis scores have been proposed as alternatives to…
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
Changes in the liver and bile ducts observed in patients diagnosed with…
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Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients.
### Background Determining the stage of fibrosis by liver biopsy is important in…
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Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis.
…The diagnostic gold standard for NASH is liver biopsy; however, other noninvasive…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
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Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.
### Objective Chronic viral hepatitis B and C cause liver fibrosis, leading to…
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
### Unlabelled The association of NAFLD with chronic hepatitis C (CHC) has been…
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
### Objective The 2019 _Standards of Medical Care in Diabetes_ suggested that patients…
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A reference material for traceability of aspartate aminotransferase (AST) results.
Standardization of aspartate aminotransferase (AST) determination is highly desirable for inter-laboratory…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
### Background & Aims The first aim was to extend the validation of FibroTest…
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PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
### Context Recently, it has been shown that an allele in the adiponutrin…
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La Haute Autorite de Sante (HAS) in France— Diagnosis of uncomplicated cirrhosis (Accessed December 2011)
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FibroTest has better diagnostic and prognostic values than the aspartate aminotransferase-to-platelet ratio index in patients with chronic hepatitis C.
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Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
Liver fibrosis (LF) must be assessed before talking treatment decisions in hepatitis…
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Glycogenic hepatopathy.
### Background Glycogenic hepatopathy (GH) is a disorder associated with uncontrolled diabetes mellitus…
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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Implementing non-invasive markers for liver fibrosis in clinical practice.
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Retracted: Executive functions in chronic hepatitis C virus infected elderly patients.
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Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
### Background & Aims Although methotrexate (MTX) is used in the effective treatment of…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.
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Screening studies of transient elastography and FibroTest in the general population.
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Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.
…The diagnostic performance of these screening strategies was statistically superior to the…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
### Background Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates…
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Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to…
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Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation.
### Background The main causes of liver fibrosis in transfusion-dependent thalassemia major…
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Noninvasive prediction of fibrosis in patients with chronic hepatitis C.
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Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.
### Aim The objective of this study was to evaluate liver fibrosis using…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
### Background And Aims Despite the high prevalence of chronic hepatitis B (CHB…
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Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
### Background And Objective Obstructive sleep apnoea (OSA) could be an independent risk…
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Applicability and variability of liver stiffness measurements according to probe position.
### Aim To investigate the liver stiffness measurement (LSM) applicability and variability with…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
Nonalcoholic fatty liver disease (NAFLD) is independently linked to cardiometabolic morbidity and…
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Clinical applicability of non-invasive markers for liver fibrosis in chronic hepatitis C (Letter)
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Guidelines for the screening, care and treatment of persons with hepatitis C infection Key publication
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
**Background/Objectives**: Prior research has identified a significant association between heart disease…
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
### Background Patients with diabetes are at risk for nonalcoholic fatty liver disease…
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Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
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The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C.
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The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
### Importance There is a need for noninvasive tools to monitor hepatotoxicity in…
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Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
### Background Few data are available on chronic hepatitis C (CHC) in elderly…
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Screening studies of transient elastography and FibroTest in the general population - Authors' reply.
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Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy.
### Background And Aim Thrombocytopenia is frequently observed in patients with chronic hepatitis…
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The use of enzyme results for liver fibrosis evaluation neccessitates standardization.
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Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
### Background The childhood/adult-onset lysosomal acid lipase deficiency (LALD; late-onset…
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Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.
…values 78.8%/81.6%; diagnostic accuracies 87.3%/88.2%. FibroScan…
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
### Background In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and…
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A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.
### Background & Aims Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease associated with…
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Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
### Background FibroTest has been validated for the diagnosis of liver fibrosis in…
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Biomarkers for liver disease in urea cycle disorders.
### Background Urea cycle disorders (UCDs) are among the most common inborn errors…
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The Distribution of Liver Steatosis, Fibrosis, Steatohepatitis and Inflammation Activity in Alcoholics According to FibroMax Test.
### Background The diagnosis of alcoholic liver diseases is based on the history…
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EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
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[The value of noninvasive serological markers in hepatitis B].
Bloodless methods (serological and imaging) for evaluating hepatic fibrosis constitute a good…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
### Aim Of The Study Was to evaluate liver disease severity in children…
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Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease.
### Background African Americans have lower reported likelihood of hepatitis C virus-related…
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Late presentation of chronic viral hepatitis for medical care: a consensus definition.
### Introduction We present two consensus definitions of advanced and late stage liver…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
### Background & Aim Fibrosis is an independent predictor of death in nonalcoholic steatohepatitis…
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Intermethod calibration of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) results: application to Fibrotest and Actitest scores.
Two multi-component scores (Fibrotest and Actitest) have been proposed to evaluate…
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Silymarin in non alcoholic fatty liver disease.
### Aim This study was undertaken to evaluate the hepatic effects of silybum…
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Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?
Liver biopsy remains the gold standard for the evaluation of fibrosis despite…
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Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.
Non-invasive biomarkers have gained popularity for estimating fibrosis stage. In our…
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Ministère des Affaires Sociales et de la Santé Key publication
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Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.
### Objective Patients with short bowel syndrome (SBS) receiving long-term parenteral nutrition…
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A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers.
In therapy with standard interferon and ribavirin, five independent risk factors (RF…
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Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…
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Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study.
### Unlabelled Physical activity (PA) is commonly recommended for nonalchoholic fatty liver disease…
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Twenty-year protocol liver biopsies: Invasive but useful for the management of liver recipients.
### Background & Aims Most liver transplant centres have discontinued the practice of protocol…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
### Background & Aims Chronic hepatitis C is both a virologic and fibrotic disease…
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Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study.
### Background & Aims Therapeutic options for patients failing hepatitis C retreatment are limited…
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Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study.
### Background The efficacy of a maintenance therapy in non-responder patients with…
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Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males.
### Unlabelled Males have strikingly increased risk of advanced liver disease. However, the…
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts.
### Background Studies have demonstrated that coronary artery calcification on one hand and…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study.
### Background Studies have demonstrated that both lower limb arterial calcification and metabolic…
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