Scientific publications for BioPredictive non-invasive diagnostics

Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.

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  1. Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.

    Chou R et al. · Ann Intern Med · 2013 Match 100

    …the platelet count, age-platelet index, aspartate aminotransferase-platelet ratio index (APRI…

    FibroTest HCV

  2. Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.

    Köksal İ et al. · Turk J Gastroenterol · 2018 Match 100

    …FibroTest®, aspartate aminotransferase-to-platelet ratio index(APRI), aspartate aminotransferase and alanine…

    FibroTest HCV

  3. Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.

    Fernandez M et al. · Eur J Gastroenterol Hepatol · 2015 Match 100

    …FS, Fibrotest, FIB-4, aspartate aminotransferase to platelet ratio index (APRI), and…

    FibroTest Alcohol

  4. Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.

    Sadler MD et al. · Can J Gastroenterol Hepatol · 2015 Match 100

    …France) M probe; aspartate aminotransferase to platelet ratio index (APRI) and FibroTest…

    FibroTest Other

  5. Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C.

    Boursier J et al. · Eur J Gastroenterol Hepatol · 2009 Match 99

    …73.8, 94.9%, aspartate aminotransferase to platelet ratio index (APRI): 71…

    FibroTest HCV

  6. Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection.

    Parikh P et al. · Ann Transl Med · 2017 Match 99

    …Due to the complex natural history of HBV infection, patients require an…

    FibroTest HBV

  7. Intestinal failure-associated liver disease in patients with short bowel syndrome: Evaluation by transient elastography.

    Knop V et al. · Nutrition · 2019 Match 99

    …The aim of the present study was to evaluate dynamic changes of…

    FibroTest SteatoTest Other

  8. Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.

    Więcek S et al. · Mediators Inflamm · 2020 Match 98

    …The aim of the study was to evaluate the selected parameters of…

    ActiTest FibroTest Other

  9. The non-invasive assessment of hepatic fibrosis.

    Gheorghe G et al. · J Formos Med Assoc · 2021 Match 98

    …The liver biopsy with the histopathological examination is considered to be the…

    ActiTest FibroTest Alcohol HBV +2

  10. Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers.

    Brühl J et al. · Eur J Gastroenterol Hepatol · 2011 Match 98

    …Established markers of fibrosis, namely, aspartate transaminase-to-platelet ratio index (APRI…

    FibroTest Other

  11. Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease.

    Lombardi R et al. · World J Gastroenterol · 2015 Match 97

    …to first tier screening of patients at risk, in order to diagnose…

    FibroTest Alcohol

  12. Comparison of non-invasive fibrosis markers and classical liver biopsy in chronic hepatitis C.

    Usluer G et al. · Eur J Clin Microbiol Infect Dis · 2012 Match 97

    …platelet ratio index (APRI), age-platelet (AP) index, Göteborg University cirrhosis index…

    FibroTest HCV

  13. Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.

    López Tórrez SM et al. · Front Nutr · 2024 Match 97

    …liver biopsy and aspartate aminotransferase-to-platelet ratio (APRI), fibrosis index-4…

    FibroTest Metabolic

  14. Progression of liver fibrosis among injection drug users with chronic hepatitis C.

    Wilson LE et al. · Hepatology · 2006 Match 97

    …Predictive values of blood markers [FibroSURE, aspartate aminotransferase-to-platelet-ratio index…

    FibroTest

  15. Non-invasive evaluation of liver fibrosis by transient elastography and biochemical markers in elderly inpatients.

    Salles N et al. · Gastroenterol Clin Biol · 2009 Match 96

    …markers (Hepascore, Aspartate Transaminase (AST) to platelet ratio index [APRI], Forns score…

    FibroTest

  16. Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.

    Beckebaum S et al. · Transplantation · 2010 Match 96

    …and 0.71 (aspartate aminotransferase-to-platelet ratio index), 0.80 and…

    FibroTest Alcohol HBV HCV +2

  17. Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B.

    Sebastiani G et al. · World J Gastroenterol · 2007 Match 96

    …AST-to-Platelet ratio (APRI), Fornso index, AST-to-ALT Ratio, Goteborg…

    FibroTest HBV

  18. Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".

    Perazzo H et al. · Clin Res Hepatol Gastroenterol · 2014 Match 95

    ### Background The aspartate aminotransferase platelet ratio index (APRI) is a validated, non…

    FibroTest Alcohol HBV HCV +1

  19. The effectiveness of noninvasive biomarkers to predict hepatitis B-related significant fibrosis and cirrhosis: a systematic review and meta-analysis of diagnostic test accuracy.

    Xu XY et al. · PLoS One · 2014 Match 95

    Noninvasive biomarkers have been developed to predict hepatitis B virus (HBV)-related…

    FibroTest HBV

  20. The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C.

    Le Calvez S et al. · Hepatology · 2004 Match 95

    FibroTest HCV

  21. Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.

    Adams LA et al. · J Gastroenterol Hepatol · 2011 Match 94

    …Cut-offs were determined by Youden Index or 90% predictive values. ### Results…

    FibroTest Metabolic

  22. Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C.

    Vergniol J et al. · Gastroenterology · 2011 Match 94

    …fibrosis (FibroTest, the aspartate aminotransferase to platelet ratio index, FIB-4), and…

    FibroTest HCV HIV

  23. Combination of fibrosis tests: sequential or synchronous?

    Boursier J et al. · Hepatology · 2009 Match 94

    FibroTest HCV

  24. Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C.

    Sebastiani G et al. · Aliment Pharmacol Ther · 2012 Match 94

    …of Fibrotest, Forns' index and AST-to-platelet ratio (APRI) have been…

    FibroTest HCV

  25. Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers.

    Vilar-Gomez E et al. · J Hepatol · 2018 Match 93

    …4 index are both cost-effective and highly sensitive tools to exclude…

    FibroTest Metabolic

  26. Evaluating the accuracy and increasing the reliable diagnosis rate of blood tests for liver fibrosis in chronic hepatitis C.

    Calès P et al. · Liver Int · 2008 Match 93

    …0.799, aspartate aminotransferase to platelet ratio index (APRI): 0.786 and…

    FibroTest HCV

  27. Noninvasive procedures to evaluate liver involvement in HIV-1 vertically infected children.

    Rubio A et al. · J Pediatr Gastroenterol Nutr · 2009 Match 93

    …SteatoTest, Forns index, aspartate aminotransferase to platelet ratio index, ultrasound, and Fibroscan…

    FibroTest HIV

  28. Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.

    Trnačević E et al. · Med Glas (Zenica) · 2021 Match 92

    Aim To assess concordance of eight frequently used serology-based scoring indices…

    FibroTest HCV

  29. Prognostic value of liver fibrosis biomarkers: a meta-analysis.

    Poynard T et al. · Gastroenterol Hepatol (N Y) · 2011 Match 92

    …such as FibroTest, aspartate transaminase-platelet ratio index (APRI), FIB-4, and…

    FibroTest Alcohol HBV HCV +3

  30. Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients.

    Stibbe KJ et al. · Scand J Gastroenterol · 2011 Match 92

    …hyaluronic acid (HA), aspartate aminotransferase platelet ratio index (APRI), FibroTest, and Fib…

    FibroTest HBV HCV

  31. Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy.

    de Lédinghen V et al. · J Pediatr Gastroenterol Nutr · 2007 Match 91

    …to compare FibroScan, Fibrotest, and aspartate transaminase to platelets ratio index (APRI…

    FibroTest HBV HCV Other

  32. Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases.

    Sebastiani G et al. · J Viral Hepat · 2008 Match 91

    …AST-to-platelet ratio, Forns' index, AST-to-ALT ratio (AAR), Fibrotest…

    FibroTest HCV

  33. Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.

    Castéra L et al. · J Hepatol · 2009 Match 91

    …AST/ALT ratio (AAR), APRI, prothrombin index (PI), platelet count (PC), FibroTest…

    FibroTest HCV

  34. Biomarkers of liver fibrosis.

    Poynard T et al. · Adv Clin Chem · 2008 Match 91

    …FT has higher accuracy than aspartate aminotransferase/platelets ratio index (APRI), the…

    ActiTest FibroTest SteatoTest Alcohol +5

  35. Non-invasive assessment of liver fibrosis: are we ready?

    Castera L et al. · Lancet · 2010 Match 90

    FibroTest Alcohol HBV HCV +1

  36. The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and Forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases.

    Adler M et al. · Hepatology · 2008 Match 90

    FibroTest Alcohol HBV HCV +1

  37. Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.

    Park MS et al. · PLoS One · 2013 Match 90

    …Here, we aimed to identify predictors of discordance between FT and liver…

    FibroTest HBV

  38. Non-invasive markers for hepatic fibrosis.

    Baranova A et al. · BMC Gastroenterol · 2011 Match 89

    …Current non-invasive methods range from serum biomarker assays to advanced imaging…

    FibroTest Alcohol HBV HCV +3

  39. Effect of antiviral treatment on serum markers of liver fibrosis in HIV-hepatitis C virus-coinfected patients: the Fibrovic 2 Study - ANRS HC02.

    Halfon P et al. · Antivir Ther · 2009 Match 89

    …Fibrotest, the Forn's index, age-platelet ratio index, SHASTA, FIB-4…

    FibroTest HCV HIV

  40. Biomarkers for liver disease in urea cycle disorders.

    Nagamani SCS et al. · Mol Genet Metab · 2021 Match 89

    ### Background Urea cycle disorders (UCDs) are among the most common inborn errors…

    ActiTest FibroTest Other

  41. Study on noninvasive laboratory tests for fibrosis in chronic HBV infection and their evaluation.

    Chen J et al. · J Clin Lab Anal · 2013 Match 88

    …were able to exclude fibrosis with a negative likelihood ratio <0.1…

    FibroTest HBV

  42. Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant.

    Bignulin S et al. · Ann Hepatol · 2016 Match 88

    …This study aimed to assess the accuracy of ARFI in discriminating liver…

    FibroTest HCV

  43. The accuracy of the FIB-4 index for the diagnosis of mild fibrosis in chronic hepatitis B.

    Mallet V et al. · Aliment Pharmacol Ther · 2009 Match 88

    …index was more precise than the AST-to-platelet ratio index and…

    FibroTest HBV

  44. Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C.

    Lewin M et al. · Hepatology · 2007 Match 88

    …06) for the aspartate aminotransferase to platelets ratio index (APRI), 0.86…

    FibroTest HCV

  45. Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.

    Calès P et al. · J Hepatol · 2010 Match 87

    ### Background & Aims We compared 5 non-specific and 2 specific blood tests…

    FibroTest HCV HIV

  46. Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.

    Castéra L et al. · Aliment Pharmacol Ther · 2011 Match 87

    …TE, Fibrotest and aspartate to platelet ratio index (APRI) the same day…

    FibroTest HBV

  47. Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.

    Poynard T et al. · Ann Intern Med · 2013 Match 87

    FibroTest HCV

  48. Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.

    Friedrich-Rust M et al. · J Clin Gastroenterol · 2010 Match 86

    …to platelet ratio index. Histologic steatosis significantly correlated with body mass index…

    FibroTest SteatoTest Other

  49. Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.

    Crisan D et al. · Hepat Mon · 2012 Match 86

    …aim of this study was to determine the accuracy of certain biomarkers…

    FibroTest HCV

  50. Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.

    Park MS et al. · Liver Int · 2015 Match 86

    …When subjects were divided into three groups according to quartile stratification (low…

    FibroTest HBV

  51. Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.

    Flores-Calderón J et al. · Ann Hepatol · 2012 Match 85

    ### Introduction Identifying liver fibrosis is important to evaluate the severity of liver…

    FibroTest

  52. Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.

    Sebastiani G et al. · Can J Gastroenterol Hepatol · 2014 Match 85

    ### Objective To determine practices among physicians in Canada for the assessment of…

    FibroTest Alcohol HBV HCV +3

  53. Effects of patient factors on noninvasive liver stiffness measurement using acoustic radiation force impulse elastography in patients with chronic hepatitis C.

    Chen SH et al. · BMC Gastroenterol · 2012 Match 85

    …METAVIR F stages, body mass index, and platelet count were also independently…

    FibroTest HCV

  54. Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis.

    Sène D et al. · Clin Biochem · 2006 Match 85

    …age-platelet, platelet, hyaluronic acid) as non-invasive alternatives to liver biopsy…

    ActiTest FibroTest HCV

  55. Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication

    Poynard T et al. · Gastroenterol Clin Biol · 2008 Match 84

    …A scoring system has been updated to better compare the quality of…

    ActiTest FibroTest SteatoTest Alcohol +5

  56. Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis.

    Castera L · J Viral Hepat · 2009 Match 84

    …Transient elastography also appears to be an excellent tool for early detection…

    FibroTest HBV HCV HIV

  57. Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.

    Matta B et al. · Curr HIV/AIDS Rep · 2016 Match 84

    Patients with HIV have a proclivity to develop liver fibrosis, especially when…

    FibroTest HBV HCV HIV

  58. Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus.

    de Lédinghen V et al. · Aliment Pharmacol Ther · 2013 Match 83

    …In multivariate analysis, FibroTest and liver stiffness had the highest hazard ratio…

    FibroTest HBV

  59. Optimized stepwise combination algorithms of non-invasive liver fibrosis scores including Hepascore in hepatitis C virus patients.

    Bourliere M et al. · Aliment Pharmacol Ther · 2008 Match 83

    …AUCs of aspartate aminotransferase (AST) to Platelets Ratio Index (APRI) and Forns…

    FibroTest HCV

  60. A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation.

    Ahmad W et al. · Virol J · 2011 Match 83

    …Different invasive and non invasive methods are applied to diagnose the disease…

    FibroTest HCV

  61. Assessment of liver fibrosis: noninvasive means.

    Poynard T et al. · Saudi J Gastroenterol · 2008 Match 82

    Liver biopsy, owing to its limitations and risks, is an imperfect gold…

    FibroTest Alcohol HBV HCV +3

  62. Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.

    Halfon P et al. · J Hepatol · 2007 Match 82

    …This has to be considered during the interpretation process. Moreover, the performance…

    FibroTest HCV

  63. The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.

    Sebastiani G et al. · Aliment Pharmacol Ther · 2011 Match 82

    …APRI, Forns'index, Lok index, AST-to-ALT ratio, Fib-4, platelets…

    FibroTest HBV HCV HIV +1

  64. Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.

    Castéra L et al. · J Hepatol · 2010 Match 82

    …FT) (Castera) or AST-to-Platelet Ratio Index (APRI) and FT (SAFE…

    FibroTest HCV

  65. Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.

    Thiele M et al. · Gastroenterology · 2018 Match 81

    …The primary aim was to validate ELF in detection of advanced fibrosis…

    FibroTest Alcohol

  66. Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.

    Cheng J et al. · PLoS One · 2015 Match 81

    …The aim of this study was to verify the diagnostic performance and…

    FibroTest HBV

  67. Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02.

    Cacoub P et al. · J Hepatol · 2008 Match 81

    …Fib-4, APRI and the Forn's index were only able to…

    FibroTest HCV HIV

  68. Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy.

    Giannini EG et al. · J Gastroenterol Hepatol · 2015 Match 80

    …The study population was subdivided according to baseline FibroSURE test results into…

    FibroTest HCV

  69. Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.

    Kim BK et al. · PLoS One · 2012 Match 80

    …We aimed to validate its diagnostic performances in comparison with liver stiffness…

    FibroTest HBV

  70. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.

    Castéra L et al. · Gastroenterology · 2005 Match 80

    …Biopredictive; and the aspartate transaminase to platelets ratio index [APRI]); a liver…

    FibroTest HCV

  71. Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.

    Harris R et al. · Lancet Gastroenterol Hepatol · 2017 Match 79

    As of 2016, there is no evidence-based pathway to stratify the…

    FibroTest Other

  72. Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive.

    Boursier J et al. · Hepatology · 2012 Match 79

    …FibroTest with the aspartate aminotransferase-to-platelet ratio index (APRI) or FibroScan…

    FibroTest HCV

  73. Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.

    Myers RP et al. · Dig Dis Sci · 2003 Match 79

    As an alternative to liver biopsy, an index of five biochemical markers…

    FibroTest HCV

  74. An independent and prospective comparison of two commercial fibrosis marker panels (HCV FibroSURE and FIBROSpect II) during albinterferon alfa-2b combination therapy for chronic hepatitis C.

    Patel K et al. · J Viral Hepat · 2009 Match 79

    …Lower index scores at baseline that continue to decline likely reflect reduced…

    FibroTest HCV

  75. Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.

    Corradi F et al. · Dig Liver Dis · 2009 Match 78

    …leading to special need of non-invasive validated methods to estimate liver…

    FibroTest HCV

  76. Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.

    Kim BK et al. · PLoS One · 2012 Match 78

    …However, to date, diagnostic performances of Enhanced Liver Fibrosis (ELF) test, which…

    FibroTest HBV

  77. Hepatitis B: are non-invasive markers of liver fibrosis reliable?

    Castera L · Liver Int · 2014 Match 78

    Liver biopsy, which was traditionally considered to be the gold standard for…

    FibroTest HBV HCV

  78. Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.

    Stasi C et al. · World J Gastroenterol · 2016 Match 77

    …suggested that the AST-to-platelet ratio index or FIB-4 test…

    FibroTest HCV

  79. A Single Test Combining Blood Markers and Elastography is More Accurate Than Other Fibrosis Tests in the Main Causes of Chronic Liver Diseases.

    Ducancelle A et al. · J Clin Gastroenterol · 2017 Match 77

    …0.750, aspartate aminotransferase platelet ratio index: 0.742, Fib-4: 0…

    FibroTest Alcohol HBV HCV +2

  80. Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers.

    Friedrich-Rust M et al. · J Thorac Cardiovasc Surg · 2008 Match 77

    …Therefore, early detection of fibrosis is essential to identify patients at risk…

    ActiTest FibroTest Other

  81. Diagnostic algorithms for liver fibrosis in hepatitis C: are they ready to avoid liver biopsy?

    Sebastiani G et al. · Hepatology · 2012 Match 76

    FibroTest HCV

  82. FIB-4: a simple, inexpensive and accurate marker of fibrosis in HCV-infected patients.

    Vallet-Pichard A et al. · Hepatology · 2006 Match 76

    FibroTest HCV

  83. Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.

    Sagrini E et al. · Eur J Gastroenterol Hepatol · 2013 Match 76

    …Age at biopsy, aspartate aminotransferase, γ-glutamyl transpeptidase, albumin, platelet count, and…

    FibroTest HCV

  84. Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.

    Akuta N et al. · J Gastroenterol · 2018 Match 75

    …4 index (FIB-4), aspartate-aminotransferase-to-platelet-ratio index] and AFP…

    FibroTest HCV

  85. FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B.

    Zeremski M et al. · BMC Gastroenterol · 2014 Match 75

    …When we combined the fibrosis score determined by FibroSURE with aspartate aminotransferase…

    ActiTest FibroTest HBV

  86. SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.

    Sebastiani G et al. · Hepatology · 2009 Match 75

    …to-platelet ratio index and Fibrotest-Fibrosure, thereby limiting liver biopsy to…

    FibroTest HCV

  87. Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review

    Moreno C et al. · J Hepatol · 2019 Match 75

    …performance to detect advanced fibrosis and cirrhosis. However, aspartate aminotransferase levels must…

    FibroTest Alcohol

  88. Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.

    Peta V et al. · World J Hepatol · 2025 Match 74

    …4 index (FIB-4) and two activity biomarkers (alanine aminotransferase (ALT) and…

    ActiTest FibroTest AIH

  89. Changes of non-invasive markers and FibroScan values during HCV treatment.

    Vergniol J et al. · J Viral Hepat · 2009 Match 74

    …The aim of this prospective study was to evaluate changes in liver…

    FibroTest HCV

  90. Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.

    Cassinotto C et al. · Radiology · 2013 Match 74

    ### Purpose To compare the diagnostic performance of acoustic radiation force impulse (ARFI…

    FibroTest Alcohol HBV HCV +2

  91. Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.

    Mossong J et al. · Bull Soc Sci Med Grand Duche Luxemb · 2011 Match 73

    ### Objective The aim of our study was to assess the diagnostic performance…

    FibroTest HCV

  92. Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication

    Shiha G et al. · Hepatol Int · 2009 Match 73

    Liver fibrosis is a common pathway leading to cirrhosis, which is the…

    FibroTest SteatoTest HBV HCV +1

  93. Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.

    de Lédinghen V et al. · Dig Liver Dis · 2012 Match 73

    …nonalcoholic fatty liver disease leading to cirrhosis. Existing guidelines do not advocate…

    FibroTest Metabolic

  94. Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection

    Match 72

    FibroTest HBV

  95. Non-invasive biomarkers of liver fibrosis in haemophilia patients with hepatitis C: can you avoid liver biopsy?

    Maor Y et al. · Haemophilia · 2006 Match 72

    …FT, AST-to-platelet ratio index (APRI), Forns index, age-platelet index…

    FibroTest HCV

  96. Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests. Key publication

    Nguyen-Khac E et al. · Aliment Pharmacol Ther · 2008 Match 72

    …Aims To assess Fibroscan for non-invasive diagnosis of asymptomatic liver fibrosis…

    FibroTest Alcohol

  97. Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.

    Haseltine EL et al. · J Viral Hepat · 2015 Match 72

    …We sought to quantify whether liver health improves following successful treatment with…

    FibroTest HCV

  98. Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication

    Naveau S et al. · Hepatology · 2009 Match 71

    …The aim of the study was to compare the diagnostic and prognostic…

    ActiTest AshTest FibroTest Alcohol

  99. Noninvasive evaluation of NAFLD.

    Castera L et al. · Nat Rev Gastroenterol Hepatol · 2013 Match 71

    A common clinical concern in patients with NAFLD is whether they have…

    ActiTest FibroTest NashTest SteatoTest +1

  100. Validation of biochemical markers for the prediction of liver fibrosis and necroinflammatory activity in hemodialysis patients with chronic hepatitis C.

    Canbakan M et al. · Nephron Clin Pract · 2011 Match 71

    …biopsy and the AST-to-platelet ratio index (APRI) in determining hepatic…

    FibroTest HCV

  101. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication

    European Association for Study of Liver et al. · J Hepatol · 2015 Match 70

    FibroTest Alcohol HBV HCV +3

  102. Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts.

    Denimal D et al. · Cardiovasc Diabetol · 2024 Match 70

    …The primary objective of the present study was to investigate whether the…

    ActiTest FibroTest NashTest SteatoTest +1

  103. Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C.

    Sebastiani G et al. · J Hepatol · 2006 Match 70

    …evaluated for AST to platelets ratio (APRI), Forns' index and Fibrotest at…

    FibroTest HCV

  104. Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.

    de Lédinghen V et al. · Liver Int · 2012 Match 69

    …The aim of this study was to prospectively evaluate the performance of…

    SteatoTest Metabolic

  105. FibroTest has better diagnostic and prognostic values than the aspartate aminotransferase-to-platelet ratio index in patients with chronic hepatitis C.

    Morra R et al. · Hepatology · 2008 Match 69

    FibroTest Alcohol HBV HCV

  106. Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B.

    Houot M et al. · Aliment Pharmacol Ther · 2016 Match 69

    …accuracy of FibroTest, aspartate aminotransferase-platelet ratio index (APRI), FIB4 or TE…

    FibroTest HBV HCV

  107. Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.

    Perazzo H et al. · Aliment Pharmacol Ther · 2014 Match 69

    …mortality and cardiovascular risk. ### Aim To evaluate the prognostic value of non…

    FibroTest SteatoTest Metabolic

  108. A novel panel of blood markers to assess the degree of liver fibrosis.

    Calès P et al. · Hepatology · 2005 Match 68

    …test combining platelets, prothrombin index, aspartate aminotransferase, alpha2-macroglobulin (A2M), hyaluronate, urea…

    FibroTest Alcohol HBV HCV

  109. Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.

    Lemoine M et al. · J Acquir Immune Defic Syndr · 2019 Match 68

    …to 0.78)], with very low specificity. Regarding NASH, alanine aminotransferase ≥36…

    FibroTest NashTest SteatoTest HIV

  110. Personalized management of cirrhosis by non-invasive tests of liver fibrosis.

    Wong GL et al. · Clin Mol Hepatol · 2015 Match 68

    Owing to the high prevalence of various chronic liver diseases, cirrhosis is…

    FibroTest Alcohol HBV HCV +1

  111. Improving estimation of liver fibrosis using combination and newer noninvasive biomarker scoring systems in hepatitis C-infected haemophilia patients.

    Maor Y et al. · Haemophilia · 2007 Match 67

    …FT, AST-to-platelet ratio index (APRI), Forns index, hyaluronic acid and…

    FibroTest HCV

  112. Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication

    Imbert-Bismut F et al. · Lancet · 2001 Match 67

    …We aimed, in our prospective study, to assess the predictive value of…

    FibroTest HCV

  113. An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Key publication

    Myers RP et al. · Can J Gastroenterol · 2012 Match 67

    …In addition, recommendations are made regarding approaches to reducing the burden of…

    FibroTest HCV

  114. Guidelines for the screening, care and treatment of persons with hepatitis C infection Key publication

    Match 66

    FibroTest HCV

  115. Validation and comparison of indexes for fibrosis and cirrhosis prediction in chronic hepatitis C patients: proposal for a pragmatic approach classification without liver biopsies.

    Bourliere M et al. · J Viral Hepat · 2006 Match 66

    …FibroTest (FT), aspartate aminotransferase to platelet ratio index (APRI) and Forns score…

    FibroTest HCV

  116. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication

    Ratziu V et al. · BMC Gastroenterol · 2006 Match 66

    …The aim of this study was to determine the diagnostic utility of…

    FibroTest Metabolic

  117. Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy.

    Bosselut N et al. · Clin Chim Acta · 2013 Match 66

    …In this study, we aimed to design a new score in chronic…

    FibroTest HCV

  118. Non-invasive diagnosis of hepatitis B virus-related cirrhosis.

    Lee S et al. · World J Gastroenterol · 2014 Match 65

    …Twenty-three percent of patients with CHB progress naturally to liver cirrhosis…

    FibroTest HBV

  119. Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study.

    Denimal D et al. · Cardiovasc Diabetol · 2025 Match 65

    …This study aimed to investigate whether the biomarkers of MASLD included in…

    ActiTest FibroTest NashTest SteatoTest +1

  120. Altered serum N-glycomics in chronic hepatitis B patients.

    Gui HL et al. · Liver Int · 2010 Match 65

    …Our present study aimed to evaluate the use of serum glycan markers…

    FibroTest HBV

  121. Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.

    Voican CS et al. · Liver Int · 2017 Match 64

    ### Background & Aims The reliability of transient elastography (TE) to assess liver fibrosis…

    FibroTest Alcohol

  122. Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study.

    Zarski JP et al. · J Hepatol · 2012 Match 64

    …Hepascore®) to 0.83 (FIB-4) for cirrhosis. ### Conclusions Contrarily to blood…

    FibroTest HCV

  123. Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.

    Schmid P et al. · PLoS One · 2015 Match 64

    ### Objectives To evaluate the diagnostic performance of seven non-invasive tests (NITs…

    FibroTest HCV HIV

  124. Fibrotest or Fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis C.

    Maor Y et al. · Haemophilia · 2010 Match 63

    Non-invasive modalities to estimate fibrosis stage are desirable in hepatitis C…

    FibroTest HCV

  125. Comparison of liver biopsy and noninvasive techniques for liver fibrosis assessment in patients infected with HCV-genotype 4 in Egypt.

    Bonnard P et al. · J Viral Hepat · 2015 Match 63

    In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to…

    FibroTest HCV

  126. Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.

    Laharie D et al. · J Hepatol · 2010 Match 63

    …The aim of this case-control study was to determine factors associated…

    FibroTest Other

  127. Noninvasive diagnosis in alcohol-related liver disease. Review

    Hadefi A et al. · Health Sci Rep · 2020 Match 63

    …Among the noninvasive surrogate markers and techniques used to detect liver fibrosis…

    FibroTest Alcohol

  128. Reproducibility of blood tests of liver fibrosis in clinical practice.

    Calès P et al. · Clin Biochem · 2008 Match 62

    ### Objectives To evaluate the inter-laboratory reproducibility of blood test for liver…

    FibroTest Alcohol HBV HCV +1

  129. Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.

    Boursier J et al. · J Hepatol · 2016 Match 62

    …score, FibroMeter(NAFLD), aspartate aminotransferase to platelet ratio index (APRI), FIB4, FibroTest…

    FibroTest Metabolic

  130. Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies.

    Poynard T et al. · Antivir Ther · 2010 Match 62

    …We aimed to review evidence-based published data of biomarkers that have…

    ActiTest FibroTest HBV HCV +1

  131. External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B.

    Poynard T et al. · Gastro Hep Adv · 2022 Match 61

    …The aim was to externally validate LCR1-LCR2 in hepatitis B. ### Methods…

    FibroTest LCR1 LCR2 Surveillance-FibroTest +1

  132. Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients.

    Bottero J et al. · J Hepatol · 2009 Match 61

    …The Kappa index was used to study overall agreement with liver biopsy…

    FibroTest HBV HIV

  133. The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.

    Younossi ZM et al. · Gastroenterology · 2021 Match 61

    …Of those with baseline F3 disease, 16.7% experienced disease progression to…

    FibroTest Metabolic

  134. The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.

    Munteanu M et al. · Am J Gastroenterol · 2011 Match 60

    FibroTest HCV

  135. Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.

    Vermehren J et al. · Liver Int · 2012 Match 60

    …liver fibrosis and cirrhosis. ### Aim To determine the diagnostic accuracy of ARFI…

    FibroTest Alcohol HBV HCV +3

  136. Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C.

    Zarski JP et al. · PLoS One · 2013 Match 60

    ### Background And Aims We aimed to determine the best algorithms for the…

    FibroTest HCV

  137. American Association for the Study of the Liver

    Match 60

    FibroTest HCV

  138. Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.

    Vermehren J et al. · BMC Gastroenterol · 2012 Match 59

    …The impact of other risk factors, including prolonged exposure to combined antiretroviral…

    FibroTest HCV HIV

  139. FibroMAX: towards a new universal biomarker of liver disease?

    Morra R et al. · Expert Rev Mol Diagn · 2007 Match 59

    …and a better benefit-to-risk ratio than biopsy of five combinations…

    ActiTest AshTest FibroTest NashTest +7

  140. Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis.

    Fierbinteanu-Braticevici C et al. · World J Gastroenterol · 2009 Match 59

    …and was superior to other noninvasive methods (APRI Index, FibroMax) for staging…

    FibroTest HCV

  141. Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review

    Bril F et al. · Diabetes Care · 2017 Match 58

    …Although the increasing prevalence of NAFLD is frequently attributed to the epidemic…

    FibroTest Metabolic

  142. Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.

    Poynard T et al. · Clin Chem · 2004 Match 58

    …The aims of this study were to assess the quality of biopsy…

    ActiTest FibroTest HCV

  143. Guidelines for the diagnosis of uncomplicated cirrhosis.

    Fontaine H et al. · Gastroenterol Clin Biol · 2007 Match 58

    FibroTest Alcohol HBV HCV +2

  144. FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus.

    Patel K et al. · World J Gastroenterol · 2011 Match 57

    ### Aim To compare histological endpoint assessment using noninvasive alternatives to biopsy during…

    FibroTest HCV

  145. Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods.

    Festi D et al. · Aliment Pharmacol Ther · 2013 Match 57

    …The articles cited were selected based on their relevancy to the objective…

    SteatoTest

  146. Noninvasive Assessment of Liver Fibrosis.

    Castera L · Dig Dis · 2015 Match 57

    …TE appears to be an excellent tool for the early detection of…

    FibroTest HBV HCV

  147. EASL clinical practical guidelines: management of alcoholic liver disease.

    European Association for the Study of Liver · J Hepatol · 2012 Match 57

    FibroTest Alcohol

  148. [Biomarkers for liver fibrosis: advances, advantages and disadvantages].

    Cequera A et al. · Rev Gastroenterol Mex · 2014 Match 56

    Liver cirrhosis in Mexico is one of the most important causes of…

    FibroTest HCV

  149. Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.

    Grattagliano I et al. · Ann Hepatol · 2013 Match 56

    The diagnostic utilities of ultrasonography (US), fatty liver index (FLI) and an…

    ActiTest FibroTest NashTest SteatoTest +1

  150. Comparative assessment of liver fibrosis by computerized morphometry in naïve patients with chronic hepatitis B and C.

    Sturm N et al. · Liver Int · 2013 Match 56

    …Hepatic stellate cell activation index was also higher in CHC than in…

    FibroTest HBV HCV

  151. Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis.

    Brener S · Ont Health Technol Assess Ser · 2015 Match 55

    …The analysis also aimed to compare the diagnostic accuracy of transient elastography…

    Elasto-FibroTest FibroTest Alcohol HBV +3

  152. Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.

    Rudler M et al. · PLoS One · 2015 Match 55

    ### Background/Aims According to guidelines, the histological diagnosis of severe alcoholic steatohepatitis…

    AshTest Alcohol

  153. Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.

    Poynard T et al. · BMJ Open · 2015 Match 55

    …lead to an increased awareness of liver disease severity. ### Objective To compare…

    ActiTest FibroTest Alcohol HBV +3

  154. The Diagnostic Value of FibroTest and Hepascore as Non-Invasive Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC).

    Cylwik B et al. · J Clin Med · 2023 Match 54

    The aim of this study was to evaluate the diagnostic usefulness of…

    FibroTest Other

  155. Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.

    Friedrich-Rust M et al. · J Cyst Fibros · 2013 Match 54

    …The aim of the present study was to evaluate the prevalence of…

    FibroTest Other

  156. Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.

    Boyd A et al. · J Int AIDS Soc · 2017 Match 54

    …The aim of this study was to evaluate the evolution of liver…

    FibroTest HBV HIV

  157. Comparison of transient elastography (FibroScan), FibroTest, APRI and two algorithms combining these non-invasive tests for liver fibrosis staging in HIV/HCV coinfected patients: ANRS CO13 HEPAVIH and FIBROSTIC collaboration.

    Castera L et al. · HIV Med · 2014 Match 54

    …Fibrotest (FT), the aspartate aminotransferase-to-platelet ratio index (APRI) and two…

    FibroTest HCV HIV

  158. FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication

    Halfon P et al. · Gastroenterol Clin Biol · 2008 Match 53

    …The primary aim of the present study was to update a previous…

    FibroTest Alcohol HBV HCV +2

  159. The new paradigm of hepatitis C therapy: integration of oral therapies into best practices.

    Afdhal NH et al. · J Viral Hepat · 2013 Match 53

    …In replacing interferon-based therapies, all-oral regimens are expected to be…

    ActiTest FibroTest HCV

  160. Management of the patient with SVR. Review

    Terrault NA et al. · J Hepatol · 2016 Match 53

    …Additional benefits include reduced morbidity related to extrahepatic and systemic manifestations of…

    FibroTest HCV

  161. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.

    Terrault NA et al. · Hepatology · 2018 Match 52

    ActiTest FibroTest HBV

  162. Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.

    Rhodes FA et al. · J Gastroenterol Hepatol · 2021 Match 52

    …Non-invasive tests (NITs) are increasingly used to detect fibrosis, but their…

    FibroTest Alcohol

  163. Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.

    Poynard T et al. · Curr Hepat Rep · 2011 Match 52

    …status, viral load, and alanine aminotransferase value. Only two biomarkers had several…

    FibroTest HBV

  164. Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes.

    Poynard T et al. · Aliment Pharmacol Ther · 2021 Match 51

    …steatohepatitis (NASH) and steatosis. ### Aims To validate externally the performances of a…

    FibroTest NashTest-2 SteatoTest Metabolic

  165. EASL Clinical Practice Guidelines: management of hepatitis C virus infection.

    European Association for the Study of the Liver · J Hepatol · 2011 Match 51

    ActiTest FibroTest HCV

  166. Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication

    AASLD/IDSA HCV Guidance Panel · Hepatology · 2015 Match 51

    ActiTest FibroTest HCV

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