Scientific publications for BioPredictive non-invasive diagnostics
Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.
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Matches for
“NAFLD fibrosis score”
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease.
…stage of fibrosis in non-alcoholic fatty liver disease (NAFLD) with results…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Noninvasive evaluation of NAFLD.
…Of the noninvasive serum markers, the NAFLD fibrosis score is the most…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.
…tests used in NAFLD patients, FibroTest for fibrosis staging, SteatoTest for steatosis…
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Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.
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Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods.
…the most accurate estimating methods are FibroMeter, FIB-4, NAFLD fibrosis score…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers.
…NAFLD fibrosis score, FIB-4 index and BARD score) or direct measures…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently…
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.
In patients with non-alcoholic fatty liver disease (NAFLD) with or without…
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Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease.
…fibrosis models across a range of fibrosis in a multi-centre NAFLD…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
Nonalcoholic fatty liver disease (NAFLD) is independently linked to cardiometabolic morbidity and…
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…disease-fibrosis score. A LB was indicated if suspected significant fibrosis (FibroScan…
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Utility of noninvasive methods for the characterization of nonalcoholic liver steatosis in the family practice. The "VARES" Italian multicenter study.
…Steatotest score was significantly associated with BMI, waist circumference, ALT, triglycerides, and…
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Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population.
…FibroTest was used to assess fibrosis degree. A structured questionnaire on coffee…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as…
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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
Chronic Obstructive Pulmonary Disease (COPD) and Non-Alcoholic Fatty Liver Disease (NAFLD…
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Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
…inflammatory activity and fibrosis in 36 patients with NAFLD (fatty liver in…
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…The prevalence rate of NAFLD was 31.1% according to AUS. The…
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…liver index score, non-alcoholic fatty liver disease fibrosis score, and SteatoTest…
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Impact of effective versus sham continuous positive airway pressure on liver injury in obstructive sleep apnoea: Data from randomized trials.
…non-alcoholic fatty liver disease (NAFLD) occurrence and progression. The impact of…
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Editorial: FibroTest to predict liver-related mortality in NAFLD. Should this change the diagnostic algorithm in NAFLD?
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…Non-invasive tests of liver fibrosis might provide a mechanism for earlier…
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The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women.
…Given that early identification of non-alcoholic fatty liver disease (NAFLD) is…
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Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease.
…fibrosis stage), LSM, and eight blood fibrosis tests (BARD, NAFLD fibrosis score…
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Fibromax-based nonalcoholic fatty liver disease in chronic obstructive pulmonary disease patients with obstructive sleep apnea: Methodological considerations.
The relationship between nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
### Background & Aims Time-dependent statistics have been used to assess liver fibrosis…
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Noninvasive, Blood-Based Biomarkers as Screening Tools for Hepatic Fibrosis in People With Type 2 Diabetes.
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Validation of noninvasive biomarkers (FibroTest, SteatoTest, and NashTest) for prediction of liver injury in patients with morbid obesity.
…Histology (NAFLD activity score, or NAFLD scoring system) and biochemical measurements were…
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts.
…However, it remains unclear whether NAFLD biomarkers could help estimate cardiovascular risk…
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
…biopsy, blood fibrosis tests (Nonalcoholic Fatty Liver Disease Fibrosis Score, FIB4, Fibrotest…
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
…for advanced fibrosis (Sp 98%). ### Conclusion In patients with NAFLD, FibroTest, a…
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Screening for liver fibrosis by using FibroScan(®) and FibroTest in patients with diabetes.
…Severe fibrosis was predicted when FibroTest was >0.59 or liver stiffness…
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Transient Elastography for Assessment of Liver Fibrosis and Steatosis: An Evidence-Based Analysis.
### Background Liver fibrosis is a sign of advanced liver disease and is…
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
…We examined the efficacy of a screening strategy with a noninvasive fibrosis…
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
…0.74-0.74) in presumed NAFLD to 0.91 (95% CI…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
…in patients with NAFLD. ### Methods 160 patients with NAFLD were prospectively included…
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Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease.
### Unlabelled Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance…
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Meta-analyses of FibroTest diagnostic value in chronic liver disease.
### Background FibroTest (FT) is a biomarker of liver fibrosis initially validated in…
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Non-invasive markers for hepatic fibrosis.
…The lack of accurate, reproducible and easily applied methods for fibrosis assessment…
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Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes.
…the three main histological features, fibrosis, non-alcoholic steatohepatitis (NASH) and steatosis…
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PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.
…The prevalence of steatosis and fibrosis was higher in minor G allele…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Routine assessment of liver fibrosis was requested by the surveyed physicians mostly…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…performance for fibrosis stage F2 (few septa) vs F1 (fibrosis without septa…
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FibroTest-ActiTest as a non-invasive marker of liver fibrosis. Key publication
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients…
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Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography.
…age 54 years, BMI 26 kg m(-) ², HCV 36%, NAFLD 25…
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
…The cardiovascular Framingham-risk score was calculated; advanced fibrosis and severe steatosis…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…score (BARD score), FibroMeter, FibroTest, enhanced liver fibrosis (ELF), Forns score, and…
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The non-invasive assessment of hepatic fibrosis.
…Liver fibrosis, as the last stage of numerous chronic liver diseases, is…
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Non-invasive markers of liver fibrosis in chronic liver disease in a group of Mexican children. A multicenter study.
…Fibrotest® score and APRI suitability to identify children with liver fibrosis. ### Material…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.
…with significant inflammatory activity or fibrosis (A2orF2) were missed by the current…
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Noninvasive Assessment of Liver Fibrosis.
…There are two clinically relevant endpoints for the staging of liver fibrosis…
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
…including 15 cases with significant fibrosis. The simplified definition increased the κ…
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Hepatoprotective Effect of Antrodia cinnamomea Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.
### Objective Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.
…HBV, and NAFLD. Identifying HIV-infected patients with significant fibrosis or cirrhosis…
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Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients.
…NAFLD without NASH, and 158 (23%) as not NAFLD. The activity score…
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data.
…score >4) 17.2%. The mean wAUROCs were: FibroTest for advanced fibrosis…
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
…In ALD, 58% had advanced fibrosis and 58% had steatosis; in non…
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FibroMAX: towards a new universal biomarker of liver disease?
…FibroTest (BioPredictive) for the quantitative assessment of fibrosis; SteatoTest (BioPredictive) for the…
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
…confirmed fibrosis were both alcoholic and nonalcoholic fatty liver disease (NAFLD) in…
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Study of FibroTest and hyaluronic acid biological variation in healthy volunteers and comparison of serum hyaluronic acid biological variation between chronic liver diseases of different etiology and fibrotic stage using confidence intervals.
### Objectives Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or…
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Noninvasive Testing for Nonalcoholic Steatohepatitis and Hepatic Fibrosis in Patients With Psoriasis Receiving Long-term Methotrexate Sodium Therapy.
…a higher NASH FibroSure hepatic fibrosis score in women (Spearman ρ = 0…
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The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.
…F3 and for ELF, NAFLD Fibrosis Score, Fibrosis-4 (FIB-4), and…
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Assessment of liver fibrosis: noninvasive means.
…For FibroTest, the mean diagnostic value for the diagnosis of advanced fibrosis…
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Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis. Review
…APRI, fibrosis-4 index, NAFLD fibrosis score, enhanced liver fibrosis (ELF) and…
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Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.
…The enhanced liver fibrosis (ELF) score was available in 396 patients. A…
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Biomarkers of liver fibrosis.
…score has been assessed in order to compare the quality of fibrosis…
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
### Background Biopsy is the usual gold standard for liver steatosis assessment. The…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.
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Performance of Plasma Biomarkers and Diagnostic Panels for Nonalcoholic Steatohepatitis and Advanced Fibrosis in Patients With Type 2 Diabetes.
…C3], FIB-4, APRI, NAFLD fibrosis score, and FibroTest). ### Results None of…
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Response to: Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications, by Jerome Boursier et al.
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Noninvasive diagnosis in alcohol-related liver disease. Review
…Among the noninvasive surrogate markers and techniques used to detect liver fibrosis…
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Noninvasive markers of fibrosis and inflammation in clinical practice: prospective comparison with liver biopsy.
### Background The efficiency of transient elastography for the assessment of liver fibrosis…
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Childhood/adult-onset lysosomal acid lipase deficiency: A serious metabolic and vascular phenotype beyond liver disease-four new pediatric cases.
…All children showed significant liver fibrosis (F3 [n = 3]; F2 [n = 1…
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
…In patients with non-advanced fibrosis (METAVIR F0F1F2), elasticity values estimated by…
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Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
### Background And Aims Gilbert syndrome (GS) is genotypically predetermined by UGT1A1*28…
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.
…These indirect comparisons assumed that the gold-standard is binary, whereas fibrosis…
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Reproducibility of blood tests of liver fibrosis in clinical practice.
…of blood test for liver fibrosis: FibroMeter, Fibrotest, APRI and their composites…
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Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.
…score, its performance to identify patients with moderate or advanced fibrosis was…
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Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
…FibroTest-T2D predicts fibrosis regression after BS. Applying 3M and adjustments could…
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Liver fibrosis markers in alcoholic liver disease.
…The evaluation of the degree of liver fibrosis is of great value…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.
…We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis.
…In recent years, the development of non-invasive tests of fibrosis allows…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Non-invasive biological tests have also been evaluated to assess liver fibrosis…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study.
…In multivariate analysis, the FibroTest® score remained independently associated with the annualized…
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A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.
…HD-UDCA significantly reduced the FibroTest® serum fibrosis marker (p<0.001…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…DAAs)), the requirement for a fibrosis score to support DDA reimbursement and…
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
### Background There is a clear need for better biomarkers of drug-induced…
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication
…As waiting for the perfect biomarker for the diagnosis of advanced fibrosis…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis.
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…gammaglutamyltranspeptidase), and a marker of fibrosis (alpha2-macroglobulin). To increase the specificity…
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Management of the patient with SVR. Review
…in those with more advanced fibrosis. To maximize the health benefits of…
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
…biopsy for the diagnosis of fibrosis in patients with chronic liver disease…
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The combination of a blood test and Fibroscan improves the non-invasive diagnosis of liver fibrosis.
…The reference was fibrosis Metavir staging. ### Results Diagnosis of significant fibrosis (Metavir…
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
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Novel Biomarkers of Grade I Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Patients with Metabolic-Dysfunction-Associated Steatotic Liver Disease.
…The prevalence of grade I LVDD, fibrosis, mild steatosis, moderate-to-severe…
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
### Background FibroTest (FT) is a validated biomarker of fibrosis. To assess the…
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Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Key publication
Liver fibrosis is a common pathway leading to cirrhosis, which is the…
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Screening studies of transient elastography and FibroTest in the general population.
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Systematic review with meta-analysis: direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B.
…TE had lower performance than FibroTest for identifying advanced fibrosis in All…
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply.
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Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients.
…severe fibrosis. ### Conclusions The synchronous association between a simple, inexpensive score and…
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Screening studies of transient elastography and FibroTest in the general population - Authors' reply.
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…for the severity of ASH-score system by the Obuchowski measures for…
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Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease.
…Currently, although several non-invasive fibrosis markers have been suggested as alternatives…
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Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.
…found between FT-related fibrosis and fibrosis stage by METAVIR scoring on…
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
…These include FibroTest (BioPredictive) for the quantitative assessment of fibrosis, and ActiTest…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
### Background Assessment of fibrosis progression in chronic liver disease relies upon non…
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Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics.
…The fibrosis stage was evaluated on the basis of FibroTest. The values…
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Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers.
…fibrosis received transient elastography and examinations for serum markers of fibrosis and…
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
BACKGROUND: Biochemical marker combinations, including alpha2-macroglobulin, haptoglobin, apolipoprotein A1, gamma-glutamyl…
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Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
…serum-based assessment of liver fibrosis is still an important diagnostic challenge…
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Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection.
…Within these populations, the diagnostic target, significant fibrosis (Metavir F > or = 2…
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Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.
…The study included 79 patients with cystic fibrosis, aged 1 to 20…
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Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests. Key publication
### Background Systematic screening for liver fibrosis in heavy-drinking patients is a…
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Assessment of allograft fibrosis by transient elastography and noninvasive biomarker scoring systems in liver transplant patients.
…a model (FibroTransplant score) to identify advanced fibrosis (F> or =3). The…
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.
…False positives of fibrosis staging (3.5%) were associated with fragmented biopsies…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.
…FibroTest-ActiTest facilitated the evaluation of both fibrosis and activity.
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B.
…glutamyl transpeptidase), a marker of fibrosis (alpha2-macroglobulin), and alpha-fetoprotein, a…
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Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease.
…Non-invasive tests (NITs) are increasingly used to detect fibrosis, but their…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation.
…tests for liver fibrosis [the Enhanced Liver Fibrosis (ELF™) test (Siemens Healthcare…
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