Scientific publications for BioPredictive non-invasive diagnostics
Peer-reviewed studies validating BioPredictive blood-test diagnostics for liver disease — from first-in-class development cohorts to long-term meta-analyses.
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“EASL, European Association for the Study of the Liver”
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European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) and European Association for the Study of Obesity (EASO) clinical practice recommendations for the management of non-alcoholic fatty liver disease: evaluation of their application in people with Type 2 diabetes.
…the European Association for the Study of the Liver, European Association for…
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.
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Late presentation of chronic viral hepatitis for medical care: a consensus definition.
…the European Association for the Study of the Liver, experts from the…
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Knowledge and practice regarding the German and the EASL-EASD-EASO NAFLD-guidelines among members of the German Obesity Society.
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Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD.
…Aims The European Association for the Study of the Liver (EASL) has…
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
…for the severity of ASH-score system by the Obuchowski measures for…
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EASL clinical practice guidelines: Management of chronic hepatitis B virus infection.
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EASL Clinical Practice Guidelines: management of hepatitis C virus infection.
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV.
…study outcome was the negative predictive value (NPV) of LCR1-LCR2 for…
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B.
…The coprimary study outcome was the negative predictive value of LCR1-LCR2…
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Noninvasive diagnosis in alcohol-related liver disease. Review
…Liver biopsy has historically been the gold standard for identifying advanced hepatic…
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Prevalence of clinically significant liver disease within the general population, as defined by non-invasive markers of liver fibrosis: a systematic review.
…The prevalence of liver fibrosis varied between 0·7% and 25·7…
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EASL clinical practical guidelines: management of alcoholic liver disease.
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Real-world efficacy and safety of ombitasvir, paritaprevir/r+dasabuvir+ribavirin in genotype 1b patients with hepatitis C virus cirrhosis.
…or liver biopsy/Fibroscan). Efficacy was assessed by the percentage of patients…
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Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey.
…Liver biopsy was the main diagnostic tool for 46.2% of the…
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Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Key publication
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FibroTest (FT) has similar accuracy for cirrhosis in 'intention-to-diagnose' which is superior to transient elastography (TE) in chronic hepatitis B.
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Impact of Type 2 Diabetes on the Accuracy of Noninvasive Tests of Liver Fibrosis With Resulting Clinical Implications.
…The study endpoint was advanced fibrosis on liver biopsy. ### Results NIT areas…
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. Key publication
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Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C.
…index calculated for the concordance analysis. Results Median age of 63 patients…
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Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study.
### Introduction Nonalcoholic fatty liver disease (NAFLD) is one of the most common…
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Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts.
…The primary objective of the present study was to investigate whether the…
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
…study highlighted in the USA the association between awareness of liver disease…
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease.
…for the prediction of liver-related death. ### Aim To validate the 10…
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Non-invasive evaluation of the liver disease severity in children with chronic viral hepatitis using FibroTest and ActiTest - comparison with histopathological assessment.
### Aim Of The Study Was to evaluate liver disease severity in children…
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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease.
…at the endpoint (death or cardiovascular event) for each liver pathology. In…
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Noninvasive evaluation of NAFLD.
…This Review discusses the advantages and limitations of noninvasive methods for the…
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.
…the validation of three blood tests used in NAFLD patients, FibroTest for…
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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests.
…We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated…
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study.
…This study aimed to investigate whether the biomarkers of MASLD included in…
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Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease.
…of NAFLD and to evaluate the relationship between various types of liver…
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
…study was to analyze the limitations of similar European (Fatty Liver Inhibition…
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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.
…Liver biopsy is currently considered as the gold standard for fibrosis assessment…
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Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis.
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
…Using liver biopsy (LB) as a reference, we assessed the accuracy of…
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Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study.
…Liver biopsy is considered the gold standard for assessment of fibrosis but…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis.
…be effective in the prediction of primary liver cancer in patients without…
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Development and validation of a nomogram based on clinical factors and standard laboratory tests for prediction of clinically significant liver fibrosis in chronic hepatitis C virus infection.
…essential for prompting surveillance and treatment. The aim of this study was…
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Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers.
…and biomarkers for liver fibrosis assessment and follow-up of hepatitis B…
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The new paradigm of hepatitis C therapy: integration of oral therapies into best practices.
…methodologies for disease screening and staging, which create the possibility of more…
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
…be effective in the prediction of primary liver cancer in patients without…
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.
…of this study was to construct a new quantitative test for the…
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Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience.
### Background The aim of this study was to compare noninvasive biomarkers, FibroTest…
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers.
…Among the 33% of patients with +/-1 Ishak stage change, FS changes…
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Toward non-invasive assessment strategies in autoimmune hepatitis.
…This study evaluates the diagnostic performance of FibroTest-Actitest, transient elastography, and…
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Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.
### Background Noninvasive tests are crucial for the management and follow-up of…
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The impact of liver disease aetiology and the stages of hepatic fibrosis on the performance of non-invasive fibrosis biomarkers: an international study of 2411 cases.
…influencing the performance of liver fibrosis biomarkers. Even after correction for DANA…
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
### Background & Aims The first aim was to extend the validation of FibroTest…
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Management of the patient with SVR. Review
In the current era of therapy with direct-acting antiviral (DAAs) drugs…
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Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease.
…We aimed to validate the diagnostic utility of TE for liver fibrosis…
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Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.
…could be utilised for the evaluation of liver fibrosis rather than other…
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Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.
…the diagnostic performance of seven non-invasive tests (NITs) of liver fibrosis…
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Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action. Review
…to worsen the course of NAFLD and the liver disease makes diabetes…
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Guidelines for the screening, care and treatment of persons with hepatitis C infection Key publication
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Meta-analyses of FibroTest diagnostic value in chronic liver disease.
…The AUROC for the diagnosis of the intermediate adjacent stages F2 vs…
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Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection.
…The detection and quantification of liver fibrosis is a key factor for…
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Finasteride and methadone use and risk of advanced hepatitis C related liver disease.
…The ethnically-divergent results for methadone associated fibrosis risk and finding of…
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Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
…for use in alcoholic liver disease (ALD). The aims of this study…
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HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.
…Therefore, we aimed to study the course of liver disease after an…
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Comparison of Fibrotest and PGAA for the diagnosis of fibrosis stage in patients with alcoholic liver disease.
…one of the first composite liver fibrosis markers. This study aims, prospectively…
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Current Possibilities to Assess the Degree of Liver Fibrosis in Patients with Haemophilia Infected with HCV--Review.
…Ease of implementation of these studies, no need for hospitalization of the…
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication
…We aimed, in our prospective study, to assess the predictive value of…
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Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.
…We compared the performance of TE with liver biopsy (LB) in patients…
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Sofosbuvir/velpatasvir in patients with hepatitis C virus genotypes 1-6 and compensated cirrhosis or advanced fibrosis.
…group for immediate treatment. We evaluated the safety and efficacy of sofosbuvir…
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
…the LFP started to increase for men at the age of 30…
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Liver stiffness measurement and biochemical markers in Senegalese chronic hepatitis B patients with normal ALT and high viral load.
…the test promoters suggested a fibrosis in 18% of cases for FT…
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
…for the diagnosis of fibrosis as compared with FibroTest (FT) and liver…
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Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
…to the FibroTest in the noninvasive identification of fibrosis, for which excess…
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Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C.
…study was to compare the performance of these two algorithms for diagnosing…
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
…liver disease (NAFLD). ### Methods Cross-sectional study of subjects from the general…
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A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease.
…for the prediction of the stage of liver fibrosis and grade of…
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Prevalence of liver cirrhosis in individuals with hepatitis B virus infection in sub-Saharan Africa: Systematic review and meta-analysis. Review
…Our primary outcome was the prevalence of cirrhosis in HBsAg-positive persons…
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure.
…The overall accuracy of AT for the diagnosis of any activity grade…
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Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography--comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease.
…Histologic staging of liver fibrosis served as the reference standard. ### Results Liver…
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
…The aim was to estimate the impact of SVR on the dynamic…
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Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.
…The study's risk of bias was assessed using the Quality Assessment…
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Non-invasive diagnosis and biomarkers in alcohol-related liver disease. Review
…Liver Fibrosis test and FibroTest have comparable performance for the diagnosis of…
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Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study).
### Background & Aims The diagnostic accuracy of non-invasive liver fibrosis tests that…
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
…The performance of biopsy was lower for the diagnosis of F2 vs…
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Accuracy of the Enhanced Liver Fibrosis Test vs FibroTest, Elastography, and Indirect Markers in Detection of Advanced Fibrosis in Patients With Alcoholic Liver Disease.
### Background & Aims Alcohol is the leading cause of cirrhosis and liver-related…
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin.
…The biochemical markers have significant predictive values both for the diagnosis of…
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Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers.
…the assessment of non-alcoholic fatty liver disease (NAFLD). Since liver biopsy…
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Biomarkers of liver fibrosis.
…standard for assessing the severity of the most frequent chronic liver diseases…
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Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV-HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study.
…The aim of this study was to evaluate the evolution of liver…
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Personalized management of cirrhosis by non-invasive tests of liver fibrosis.
…accurate diagnosis of cirrhosis and reduces the need for liver biopsy. In…
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FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis.
### Objectives Extent of liver fibrosis is one of the most important factors…
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Non-invasive diagnosis of hepatitis B virus-related cirrhosis.
…Liver biopsy is the reference standard for assessment of liver fibrosis. However…
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Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
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Ministère des Affaires Sociales et de la Santé Key publication
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Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection
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