Ratziu V
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Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
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Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.
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External Validation of LCR1-LCR2, a Multivariable Hepatocellular Carcinoma Risk Calculator, in a Multiethnic Cohort of Patients With Chronic Hepatitis B.
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Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study.
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External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV.
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Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.
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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. Key publication
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Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis.
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LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis. Key publication
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The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication
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Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.
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Impact of steatosis and inflammation definitions on the performance of NASH tests.
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Long-term prognostic value of the FibroTest in patients with non-alcoholic fatty liver disease, compared to chronic hepatitis C, B, and alcoholic liver disease.
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Screening studies of transient elastography and FibroTest in the general population.
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Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.
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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
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Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity.
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Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.
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Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.
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Staging chronic hepatitis B into seven categories, defining inactive carriers and assessing treatment impact using a fibrosis biomarker (FibroTest®) and elastography (FibroScan®).
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Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®).
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Variability in definitions of transaminase upper limit of the normal impacts the APRI performance as a biomarker of fibrosis in patients with chronic hepatitis C: "APRI c'est fini ?".
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Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection.
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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification.
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Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease.
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Liver fibrosis evaluation using real-time shear wave elastography: applicability and diagnostic performance using methods without a gold standard.
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Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C.
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Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis.
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Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data.
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Performances of Elasto-FibroTest(®), a combination between FibroTest(®) and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C.
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Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard.
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Validation of liver fibrosis biomarker (FibroTest) for assessing liver fibrosis progression: proof of concept and first application in a large population.
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A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.
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Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.
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FibroStic: a large confirmatory study for non-invasive biomarkers accuracy, if correctly interpreted.
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FibroTest and Fibroscan performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate.
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HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C.
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Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B.
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Prognostic value of liver fibrosis biomarkers: a meta-analysis.
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The risk of multiplying diagnostic combinations in the absence of a perfect gold standard for a fibrosis test.
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ActiTest accuracy for the assessment of histological activity grades in patients with chronic hepatitis C, an overview using Obuchowski measure.
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Biomarkers of liver injury for hepatitis clinical trials: a meta-analysis of longitudinal studies.
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Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).
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Applicability and variability of liver stiffness measurements according to probe position.
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Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C.
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Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus. Key publication
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Liver biopsy: the best standard...when everything else fails.
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The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
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The risks of changing the rules for previously validated biomarkers and using the same patients several times. Response letter to Calès et al. Gastroenterol Clin Biol 2008;32:1050-60: "Evaluation and improvement of a reliable diagnosis of cirrhosis by blood tests".
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An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. Key publication
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Assessment of liver fibrosis: noninvasive means.
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Biomarkers of liver fibrosis.
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Concordance in a world without a gold standard: a new non-invasive methodology for improving accuracy of fibrosis markers.
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FibroTest has better diagnostic and prognostic values than the aspartate aminotransferase-to-platelet ratio index in patients with chronic hepatitis C.
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FibroTest is effective in patients with normal transaminases, when accuracy is standardized on fibrosis stage prevalence.
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Methodological aspects of the interpretation of non-invasive biomarkers of liver fibrosis: a 2008 update. Key publication
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Noninvasive biomarkers for the screening of fibrosis, steatosis and steatohepatitis in patients with metabolic risk factors: FibroTest-FibroMax experience. Key publication
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Reproducibility of non-invasive fibrosis biomarkers, FibroMeter and FibroTest, could be improved by respecting the analytical standardizations.
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Screening for liver fibrosis by using a noninvasive biomarker in patients with diabetes.
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Diagnostic value of serum protein profiling by SELDI-TOF ProteinChip compared with a biochemical marker, FibroTest, for the diagnosis of advanced fibrosis in patients with chronic hepatitis C.
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FibroMAX: towards a new universal biomarker of liver disease?
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Meta-analyses of FibroTest diagnostic value in chronic liver disease.
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Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
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Standardization of ROC curve areas for diagnostic evaluation of liver fibrosis markers based on prevalences of fibrosis stages. Key publication
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Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation.
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A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Key publication
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Diagnostic value of FibroTest with normal serum aminotransferases.
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Key publication
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. Key publication
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Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?
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The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease.
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Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy?
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Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease.
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FibroTest-FibroSURE: towards a universal biomarker of liver fibrosis?
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Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
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The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Key publication
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Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest).
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Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
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Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C.
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The predictive value of Fibrotest vs. APRI for the diagnosis of fibrosis in chronic hepatitis C.
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Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index.
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Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B.
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Serum biochemical markers accurately predict liver fibrosis in HIV and hepatitis C virus co-infected patients.
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Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial.
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Biochemical markers of liver fibrosis: a comparison with historical features in patients with chronic hepatitis C.
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Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Key publication