Scientific publications for BioPredictive non-invasive diagnostics

Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference.

Munteanu M et al. · Aliment Pharmacol Ther · 2016 Match 100

…grading/staging of the SAF scoring system across the three elementary features…

ActiTest FibroTest SteatoTest Metabolic

Impact of steatosis and inflammation definitions on the performance of NASH tests.

Poynard T et al. · Eur J Gastroenterol Hepatol · 2018 Match 98

### Background And Aim One of the unmet needs in subjects with metabolic…

ActiTest FibroTest NashTest NashTest-2 +3

Diagnostic performance of a new noninvasive test for nonalcoholic steatohepatitis using a simplified histological reference.

Poynard T et al. · Eur J Gastroenterol Hepatol · 2018 Match 96

### Background One of the unmet needs in patients with metabolic risks is…

FibroTest NashTest SteatoTest Metabolic

Prospective external validation of a new non-invasive test for the diagnosis of non-alcoholic steatohepatitis in patients with type 2 diabetes.

Poynard T et al. · Aliment Pharmacol Ther · 2021 Match 93

### Background One of the unmet needs in patients with type 2 diabetes…

FibroTest NashTest-2 SteatoTest Metabolic

Prospective direct comparison of non-invasive liver tests in outpatients with type 2 diabetes using intention-to-diagnose analysis.

Poynard T et al. · Aliment Pharmacol Ther · 2023 Match 91

FibroTest-T2D NashTest-T2D SteatoTest-T2D Metabolic

Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients.

Bedossa P et al. · Hepatology · 2012 Match 89

…The aim was to build an algorithm along with a scoring system…

Metabolic

Clinical Interest of Serum Alpha-2 Macroglobulin, Apolipoprotein A1, and Haptoglobin in Patients with Non-Alcoholic Fatty Liver Disease, with and without Type 2 Diabetes, before or during COVID-19.

Deckmyn O et al. · Biomedicines · 2022 Match 86

In patients with non-alcoholic fatty liver disease (NAFLD) with or without…

FibroTest Metabolic

The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis. Key publication

Poynard T et al. · Eur J Gastroenterol Hepatol · 2019 Match 84

### Background Serum biomarkers of steatosis such as the SteatoTest are recommended for…

NashTest-2 SteatoTest-2 Metabolic

Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.

Poynard T et al. · Hepatol Commun · 2023 Match 81

### Background And Aims Gilbert syndrome (GS) is genotypically predetermined by UGT1A1*28…

FibroTest

Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes.

Poynard T et al. · Eur J Gastroenterol Hepatol · 2020 Match 79

### Objective There is a controversy about the performance of blood tests for…

FibroTest NashTest-2 SteatoTest-2 Metabolic

Validation of AshTest as a Non-Invasive Alternative to Transjugular Liver Biopsy in Patients with Suspected Severe Acute Alcoholic Hepatitis.

Rudler M et al. · PLoS One · 2015 Match 77

…the severity of ASH-score system by the Obuchowski measures for [mean…

AshTest Alcohol

Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.

Perazzo H et al. · Aliment Pharmacol Ther · 2014 Match 74

### Background In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and…

FibroTest SteatoTest Metabolic

EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease.

European Association for the Study of the Liver (EASL) et al. · Obes Facts · 2016 Match 72

FibroTest SteatoTest Metabolic

Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.

Dominguez S et al. · J Antimicrob Chemother · 2010 Match 70

…Seventy-five percent of co-infected patients scoring F4, 33% of those…

FibroTest HCV HIV

Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study.

Lemoine M et al. · J Acquir Immune Defic Syndr · 2019 Match 67

### Background HIV-monoinfected individuals are at high risk of nonalcoholic fatty liver…

FibroTest NashTest SteatoTest HIV

Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Key publication

Naveau S et al. · Hepatology · 2009 Match 65

FibroTest has been validated as a biomarker of fibrosis in patients with…

ActiTest AshTest FibroTest Alcohol

Three Neglected STARD Criteria Reduce the Uncertainty of the Liver Fibrosis Biomarker FibroTest-T2D in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Poynard T et al. · Diagnostics (Basel) · 2025 Match 62

**Background/Objectives:** Bariatric surgery (BS), drugs approved for type-2-diabetes (T2D…

FibroTest-T2D Metabolic

The Association of Histologic and Noninvasive Tests With Adverse Clinical and Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis.

Younossi ZM et al. · Gastroenterology · 2021 Match 60

### Background & Aim Fibrosis is an independent predictor of death in nonalcoholic steatohepatitis…

FibroTest Metabolic

Accuracy of prognostic serological biomarkers in predicting liver fibrosis severity in people with metabolic dysfunction-associated steatotic liver disease: a meta-analysis of over 40,000 participants.

López Tórrez SM et al. · Front Nutr · 2024 Match 58

### Introduction A prognostic model to predict liver severity in people with metabolic…

FibroTest Metabolic

Guidelines for the screening, care and treatment of persons with hepatitis C infection Key publication

Match 55

FibroTest HCV

Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection

Match 53

FibroTest HBV